Atrial Fibrillation, Brain Volumes, and Subclinical Cerebrovascular Disease (from the Atherosclerosis Risk in Communities Neurocognitive Study [ARIC-NCS]).
Aged
Atherosclerosis
/ complications
Atrial Fibrillation
/ complications
Brain
/ pathology
Cerebrovascular Disorders
/ diagnosis
Cognition
/ physiology
Female
Follow-Up Studies
Humans
Incidence
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Organ Size
Prospective Studies
Risk Assessment
/ methods
Risk Factors
United States
/ epidemiology
Journal
The American journal of cardiology
ISSN: 1879-1913
Titre abrégé: Am J Cardiol
Pays: United States
ID NLM: 0207277
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
17
07
2019
revised:
30
09
2019
accepted:
02
10
2019
pubmed:
28
11
2019
medline:
23
4
2020
entrez:
28
11
2019
Statut:
ppublish
Résumé
The aim of the present study was to investigate the association between atrial fibrillation (AF) and total and regional brain volumes among participants in the community-based Atherosclerosis Risk in Communities Neurocognitive study (ARIC-NCS). A total of 1,930 participants (130 with AF) with a mean age of 76.3 ± 5.2, who underwent 3T brain MRI scans in 2011 to 2013 were included. Prevalent AF was ascertained from study ECGs and hospital discharge codes. Brain volumes were measured using FreeSurfer image analysis software. Markers of subclinical cerebrovascular disease included lobar microhemorrhages, subcortical microhemorrhages, cortical infarcts, subcortical infarcts, lacunar infarcts, and volume of white matter hyperintensities. Linear regression models were used to assess the associations between AF status and brain volumes. In adjusted analyses, AF was not associated with markers of subclinical cerebrovascular disease. However, AF was associated with smaller regional brain volumes (including temporal, occipital, and parietal lobes; deep gray matter; Alzheimer disease signature region; and hippocampus [all p <0.05]) after controlling for demographics, cardiovascular risk factors, prevalent cardiovascular disease, and markers of subclinical cerebrovascular disease. Subgroup analysis revealed a significant interaction between AF and total brain volume with respect to age (p = 0.02), with associations between AF and smaller brain volumes being stronger for older individuals. In conclusion, AF was associated with smaller brain volumes, and the association was stronger among older individuals. This finding may be related to the longer exposure period of the older population to AF or the possibility that older people are more susceptible to the effects of AF on brain volume.
Identifiants
pubmed: 31771759
pii: S0002-9149(19)31156-7
doi: 10.1016/j.amjcard.2019.10.010
pmc: PMC6942172
mid: NIHMS1065467
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
222-228Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096814
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070825
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL130025
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 16EIA26410001
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL148521
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
Stroke. 2013 Apr;44(4):1020-5
pubmed: 23444303
Ann Intern Med. 2013 Mar 5;158(5 Pt 1):338-46
pubmed: 23460057
Stroke. 1994 Feb;25(2):318-27
pubmed: 8303738
Heart Rhythm. 2012 Nov;9(11):1761-8
pubmed: 22863685
Neurology. 2004 Nov 23;63(10):1892-7
pubmed: 15557507
Neurology. 2004 Nov 9;63(9):1591-9
pubmed: 15534241
J Cereb Blood Flow Metab. 1989 Jun;9(3):422-5
pubmed: 2715212
N Engl J Med. 1998 Sep 24;339(13):861-7
pubmed: 9744969
Heart Rhythm. 2016 Oct;13(10):2020-4
pubmed: 27417740
Am Heart J. 2009 Jul;158(1):111-7
pubmed: 19540400
Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
Am J Epidemiol. 1989 Apr;129(4):687-702
pubmed: 2646917
J Am Heart Assoc. 2018 Mar 7;7(6):
pubmed: 29514809
Stroke. 2015 Feb;46(2):433-40
pubmed: 25563642
J Am Heart Assoc. 2014 Aug 20;3(4):
pubmed: 25142059
Heart Rhythm. 2010 Apr;7(4):433-7
pubmed: 20122875
Stroke. 1999 Apr;30(4):736-43
pubmed: 10187871
Neurology. 2011 Apr 19;76(16):1395-402
pubmed: 21490323
Europace. 2018 Aug 1;20(8):1252-1258
pubmed: 29016776
Stroke. 2014 Sep;45(9):2568-74
pubmed: 25052319
Circulation. 2011 Nov 1;124(18):1982-93
pubmed: 22042927
Am J Cardiol. 2008 Apr 1;101(7):1016-22
pubmed: 18359324
Diabetes Care. 2013 Jan;36(1):90-7
pubmed: 22933440
Alzheimers Dement (Amst). 2016;2:1-11
pubmed: 26949733
Neurology. 2009 Apr 28;72(17):1519-25
pubmed: 19398707
Eur Heart J. 2008 Sep;29(17):2125-32
pubmed: 18667399
Stroke. 2011 May;42(5):1255-60
pubmed: 21493917
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223