An MPER antibody neutralizes HIV-1 using germline features shared among donors.
Antibodies, Monoclonal
/ immunology
Antibodies, Neutralizing
/ immunology
Cell Membrane
/ metabolism
Cryoelectron Microscopy
Crystallography, X-Ray
Drug Resistance, Viral
/ genetics
Epitopes
HIV Envelope Protein gp41
/ chemistry
HIV-1
/ drug effects
Humans
Hydrophobic and Hydrophilic Interactions
Immunoglobulin Fab Fragments
/ chemistry
Immunoglobulin G
/ chemistry
Protein Conformation
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
26 11 2019
26 11 2019
Historique:
received:
22
03
2019
accepted:
11
10
2019
entrez:
28
11
2019
pubmed:
28
11
2019
medline:
14
4
2020
Statut:
epublish
Résumé
The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies of exceptional breadth. MPER antibodies usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors, are often from the minor IgG3 subclass, and some are polyreactive, such as 4E10. Here we describe an MPER broadly neutralizing antibody from the major IgG1 subclass, PGZL1, which shares germline V/D-region genes with 4E10, has a shorter CDRH3, and is less polyreactive. A recombinant sublineage variant pan-neutralizes a 130-isolate panel at 1.4 μg/ml (IC
Identifiants
pubmed: 31772165
doi: 10.1038/s41467-019-12973-1
pii: 10.1038/s41467-019-12973-1
pmc: PMC6879610
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Epitopes
0
HIV Envelope Protein gp41
0
Immunoglobulin Fab Fragments
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5389Subventions
Organisme : NIAID NIH HHS
ID : UM1 AI144462
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI100663
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143563
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129698
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114401
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103393
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI036214
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI124337
Pays : United States
Investigateurs
George Miiro
(G)
Jennifer Serwanga
(J)
Anton Pozniak
(A)
Dale McPhee
(D)
Oliver Manigart
(O)
Lawrence Mwananyanda
(L)
Etienne Karita
(E)
André Inwoley
(A)
Walter Jaoko
(W)
Jack DeHovitz
(J)
Linda-Gail Bekker
(LG)
Punnee Pitisuttithum
(P)
Robert Paris
(R)
Susan Allen
(S)
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