Robo4 contributes to the turnover of Peyer's patch B cells.
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
01
04
2019
accepted:
04
11
2019
revised:
21
10
2019
pubmed:
28
11
2019
medline:
20
1
2021
entrez:
28
11
2019
Statut:
ppublish
Résumé
All leukocytes can get entrance into the draining lymph nodes via the afferent lymphatics but only lymphoid cells can leave the nodes. The molecular mechanisms behind this phenomenon have remained unknown. We employed genome wide microarray analyses of the subcapsular sinus and lymphatic sinus (LS) endothelial cells and found Robo4 to be selectively expressed on LS lymphatics. Further analyses showed high Robo4 expression in lymphatic vessels of Peyer's patches, which only have efferent lymphatic vessels. In functional assays, Robo4-deficient animals showed accumulation of naïve B cells (CD19
Identifiants
pubmed: 31772321
doi: 10.1038/s41385-019-0230-9
pii: S1933-0219(22)00290-2
doi:
Substances chimiques
Antibodies, Blocking
0
Receptors, Cell Surface
0
Robo4 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
245-256Références
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