Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation.
Journal
Neural plasticity
ISSN: 1687-5443
Titre abrégé: Neural Plast
Pays: United States
ID NLM: 100883417
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
05
2019
revised:
30
08
2019
accepted:
16
09
2019
entrez:
28
11
2019
pubmed:
28
11
2019
medline:
28
7
2020
Statut:
epublish
Résumé
The perineuronal net (PNN) is a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity. The PNN regulates plasticity via multiple pathways, one of which is direct regulation of synapses through the control of AMPA receptor mobility. Since neuronal pentraxin 2 (Nptx2) is a known regulator of AMPA receptor mobility and Nptx2 can be removed from the neuronal surface by PNN removal, we investigated whether Nptx2 has a function in the PNN. We found that Nptx2 binds to the glycosaminoglycans hyaluronan and chondroitin sulphate E in the PNN. Furthermore, in primary cortical neuron cultures, the addition of NPTX2 to the culture medium enhances PNN formation during PNN development. These findings suggest Nptx2 as a novel PNN binding protein with a role in the mechanism of PNN formation.
Identifiants
pubmed: 31772567
doi: 10.1155/2019/6804575
pmc: PMC6854953
doi:
Substances chimiques
Nerve Tissue Proteins
0
neuronal pentraxin
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6804575Subventions
Organisme : Medical Research Council
ID : MC_PC_16050
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R004463/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R004544/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Heleen M. Van't Spijker et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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