Interleukin-6 and Interleukin-15 as Possible Biomarkers of the Risk of Autoimmune Diabetes Development.
Adolescent
Adult
Antibodies, Anti-Idiotypic
/ blood
Biomarkers
/ blood
Blood Glucose
Diabetes Mellitus, Type 1
/ blood
Female
Humans
Insulin
/ blood
Insulin Resistance
/ immunology
Insulin-Secreting Cells
/ immunology
Interleukin-15
/ blood
Interleukin-6
/ blood
Latent Autoimmune Diabetes in Adults
/ blood
Male
Middle Aged
Risk Factors
Young Adult
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
05
2019
accepted:
07
08
2019
entrez:
28
11
2019
pubmed:
28
11
2019
medline:
9
4
2020
Statut:
epublish
Résumé
The aim of our study was to assay circulating interleukin-15 (IL-15) and interleukin-6 (IL-6) levels and insulin resistance measured by two different methods in newly diagnosed autoimmune diabetes (AD) patients, their I° relatives, and healthy controls. The group studied consisted of 54 patients with AD (28 with Latent Autoimmune Diabetes in Adults (LADA) and 26 with type 1 diabetes (T1D)), 70 first-degree relatives, and 60 controls. IL-6, IL-15, and anti-islet antibodies concentrations were measured by ELISA method. Homeostatic model assessment-insulin resistance (HOMAIR) and estimated glucose disposal rate (eGDR) were calculated. The patients with AD had significantly higher IL-15, IL-6, and HOMAIR and lower eGDR than the controls ( Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development, in particular IL-15 for LADA. Both methods of IR measurement appear equally useful for calculating insulin resistance in autoimmune diabetes.
Identifiants
pubmed: 31772933
doi: 10.1155/2019/4734063
pmc: PMC6854156
doi:
Substances chimiques
Antibodies, Anti-Idiotypic
0
Biomarkers
0
Blood Glucose
0
Insulin
0
Interleukin-15
0
Interleukin-6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4734063Informations de copyright
Copyright © 2019 Katarzyna Siewko et al.
Déclaration de conflit d'intérêts
None of the authors has any potential financial conflict.
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