Reconfiguration of large-scale functional connectivity in patients with disorders of consciousness.
disorders of consciousness
functional connectivity
integration
segregation and centrality network measurements
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
19
06
2019
revised:
23
08
2019
accepted:
11
10
2019
pubmed:
28
11
2019
medline:
29
12
2020
entrez:
28
11
2019
Statut:
ppublish
Résumé
Functional connectivity alterations within individual resting state networks (RSNs) are linked to disorders of consciousness (DOC). If these alterations influence the interaction quality with other RNSs, then, brain alterations in patients with DOC would be characterized by connectivity changes in the large-scale model composed of RSNs. How are functional interactions between RSNs influenced by internal alterations of individual RSNs? Do the functional alterations induced by DOC change some key properties of the large-scale network, which have been suggested to be critical for the consciousness emergence? Here, we use network analysis to measure functional connectivity in patients with DOC and address these questions. We hypothesized that network properties provide descriptions of brain functional reconfiguration associated with consciousness alterations. We apply nodal and global network measurements to study the reconfiguration linked with the disease severity. We study changes in integration, segregation, and centrality properties of the functional connectivity between the RSNs in subjects with different levels of consciousness. Our analysis indicates that nodal measurements are more sensitive to disease severity than global measurements, particularly, for functional connectivity of sensory and cognitively related RSNs. The network property alterations of functional connectivity in different consciousness levels suggest a whole-brain topological reorganization of the large-scale functional connectivity in patients with DOC.
Identifiants
pubmed: 31773918
doi: 10.1002/brb3.1476
pmc: PMC6955826
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1476Subventions
Organisme : Universidad Nacional de Colombia
ID : 37568
Pays : International
Organisme : Departamento Administrativo de Ciencia, Tecnología e Innovación
ID : 5007-744-55796
Pays : International
Organisme : Fonds De La Recherche Scientifique - FNRS
ID : 9.4501.12
Pays : International
Organisme : Gobernación del Magdalena e Instituto Colombiano para el desarrollo de la Ciencia y la Tecnología
Pays : International
Informations de copyright
© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
Références
Lancet Neurol. 2016 Jul;15(8):830-842
pubmed: 27131917
Epilepsy Behav. 2014 Jan;30:28-32
pubmed: 24100252
Hum Brain Mapp. 1998;6(3):160-88
pubmed: 9673671
Curr Opin Neurobiol. 2013 Apr;23(2):239-44
pubmed: 23273731
Biometrika. 1947;34(1-2):28-35
pubmed: 20287819
Cortex. 2014 Mar;52:35-46
pubmed: 24480455
Nat Rev Neurosci. 2012 Apr 13;13(5):336-49
pubmed: 22498897
Nat Rev Neurosci. 2007 Sep;8(9):700-11
pubmed: 17704812
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Neuroimage. 2008 Feb 15;39(4):1666-81
pubmed: 18082428
Eur Neuropsychopharmacol. 2010 Aug;20(8):519-34
pubmed: 20471808
Front Psychol. 2012 Aug 27;3:295
pubmed: 22969735
Neuroimage. 2019 Jul 15;195:354-361
pubmed: 30862533
Neuroimage. 2010 Dec;53(4):1197-207
pubmed: 20600983
Brain Connect. 2013;3(3):273-85
pubmed: 23547875
Neuroimage. 2012 Aug 15;62(2):938-44
pubmed: 22326802
Br J Anaesth. 2017 Oct 1;119(4):674-684
pubmed: 29121293
Philos Trans R Soc Lond B Biol Sci. 2015 May 19;370(1668):
pubmed: 25823865
Ann N Y Acad Sci. 2008 Mar;1124:239-61
pubmed: 18400934
Ann N Y Acad Sci. 2008;1129:119-29
pubmed: 18591474
Proc Natl Acad Sci U S A. 1994 May 24;91(11):5033-7
pubmed: 8197179
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Brain Behav. 2017 Feb 16;7(3):e00626
pubmed: 28293468
Neurology. 2015 Mar 24;84(12):1272-80
pubmed: 25713001
Neuroimage. 2012 Aug 15;62(2):1267-71
pubmed: 22261374
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53
pubmed: 16945915
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13
pubmed: 16087444
Dialogues Clin Neurosci. 2013 Sep;15(3):247-62
pubmed: 24174898
World J Radiol. 2014 Aug 28;6(8):589-97
pubmed: 25170396
Neurol Sci. 2011 Oct;32(5):773-85
pubmed: 21667095
Brain Behav. 2020 Jan;10(1):e1476
pubmed: 31773918
J Clin Med. 2019 Mar 05;8(3):
pubmed: 30841486
Brain Inj. 2008 Sep;22(10):786-92
pubmed: 18787989
Neuroimage. 2012 Jun;61(2):478-91
pubmed: 22227888
Anesth Analg. 2017 Feb;124(2):588-598
pubmed: 27941576
Arch Phys Med Rehabil. 2004 Dec;85(12):2020-9
pubmed: 15605342
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:2793-6
pubmed: 25570571
Trends Cogn Sci. 2013 Dec;17(12):641-7
pubmed: 24238779
PLoS One. 2010 Apr 27;5(4):e10232
pubmed: 20436911