A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure-activity relationships in alveolar macrophages.
Animals
Biomarkers
Cell Line
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Humans
Macrophages, Alveolar
/ drug effects
Manganese Compounds
/ chemistry
Metabolomics
/ methods
Nanostructures
/ chemistry
Oxides
/ chemistry
Particle Size
Proteomics
/ methods
Rats
Selenium Oxides
/ chemistry
Structure-Activity Relationship
Surface Properties
src Homology Domains
/ drug effects
Nanomaterials
SH2 profiling
WGCNA
alveolar macrophages
metabolomics
multi-omics
proteomics
Journal
Nanotoxicology
ISSN: 1743-5404
Titre abrégé: Nanotoxicology
Pays: England
ID NLM: 101233132
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
pubmed:
28
11
2019
medline:
17
6
2020
entrez:
28
11
2019
Statut:
ppublish
Résumé
In respect to the high number of released nanomaterials and their highly variable properties, novel grouping approaches are required based on the effects of nanomaterials. Proper grouping calls for a combination of an experimental setup with a higher number of structurally similar nanomaterials and for employing integrated omics approaches to identify the mode of action. Here, we analyzed the effects of seven well-characterized NMs comprising different chemical compositions, sizes and chemical surface modifications on the rat alveolar macrophage cell line NR8383. The NMs were investigated at three doses ranging from 2.5 to 10 µg/cm
Identifiants
pubmed: 31774342
doi: 10.1080/17435390.2019.1684592
doi:
Substances chimiques
Biomarkers
0
Manganese Compounds
0
Oxides
0
Selenium Oxides
0
manganese oxide
64J2OA7MH3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM