Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.

Cell Differentiation Epithelial Cells / metabolism Humans Proteomics / methods Thymus Gland / physiopathology
Psmb11 cortical thymic epithelial cells cyclin D1 medullary thymic epithelial cells proteome thymoproteasome trans-omics

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
26 11 2019
Historique:
received: 15 04 2019
revised: 27 08 2019
accepted: 18 10 2019
entrez: 28 11 2019
pubmed: 28 11 2019
medline: 21 10 2020
Statut: ppublish

Résumé

The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighted a rich diversity in functional mTEC subpopulations. Because of their limited cellularity, however, the biochemical characterization of TECs, including the proteomic profiling of cTECs and mTECs, has remained unestablished. Utilizing genetically modified mice that carry enlarged but functional thymuses, here we show a combination of proteomic and transcriptomic profiles for cTECs and mTECs, which identified signature molecules that characterize a developmental and functional contrast between cTECs and mTECs. Our results reveal a highly specific impact of the thymoproteasome on proteasome subunit composition in cTECs and provide an integrated trans-omics platform for further exploration of thymus biology.

Identifiants

DOI: 10.1016/j.celrep.2019.10.079 PMID: 31775054 PMC: PMC6897492
pubmed: 31775054
pii: S2211-1247(19)31401-9
doi: 10.1016/j.celrep.2019.10.079
pmc: PMC6897492
mid: NIHMS1544761
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2901-2916.e6

Subventions

Organisme : Intramural NIH HHS
ID : ZIA BC011806-01
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Published by Elsevier Inc.

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Auteurs

Izumi Ohigashi (I)

Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.

Yu Tanaka (Y)

Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

Kenta Kondo (K)

Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

Sayumi Fujimori (S)

Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.

Hiroyuki Kondo (H)

Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.

Amy C Palin (AC)

Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

Victoria Hoffmann (V)

Division of Veterinary Resources, Office of Research Services, NIH, Bethesda, MD 20892, USA.

Mina Kozai (M)

Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.

Yosuke Matsushita (Y)

Division of Genome Medicine, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.

Shinsuke Uda (S)

Division of Integrated Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.

Ryo Motosugi (R)

Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

Jun Hamazaki (J)

Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

Hiroyuki Kubota (H)

Division of Integrated Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.

Shigeo Murata (S)

Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

Keiji Tanaka (K)

Tokyo Metropolitan Institute for Medical Science, Tokyo 156-8506, Japan.

Toyomasa Katagiri (T)

Division of Genome Medicine, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.

Hidetaka Kosako (H)

Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.

Yousuke Takahama (Y)

Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: yousuke.takahama@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Trans-omics Impact of Thymoproteasome in...
questionsmedicales.fr › Cellules › Cellules épithéliales › Trans-omics Impact of Thymoproteasome in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Trans-omics Impact of Thymoproteasome in...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Trans-omics Impact of Thymoproteasome in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Thymus (glande) › Trans-omics Impact of Thymoproteasome in...