Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol.
Aging
Exosomes
Extracellular vesicles
Female reproduction
Fertility
Systematic review
miRNAs
Journal
Systematic reviews
ISSN: 2046-4053
Titre abrégé: Syst Rev
Pays: England
ID NLM: 101580575
Informations de publication
Date de publication:
28 11 2019
28 11 2019
Historique:
received:
16
04
2019
accepted:
11
11
2019
entrez:
29
11
2019
pubmed:
30
11
2019
medline:
26
8
2020
Statut:
epublish
Résumé
Exosomes may have critical roles in the maternal-embryo cross-talk for the recognition and maintenance of pregnancy during maternal aging. Exosomes have the capability to carry developmental signaling molecules with the ability to modulate gene expressions and affect growth and regulation of embryo during pregnancy. Systematic review aims to evaluate age-related alterations in the exosomal content and functions that can influence the reproductive performance in human and animal models as conveyors of senescence signals. A literature search of electronic databases including MEDLINE (PubMed), Embase, ProQuest, Scopus, Google Scholar, WHO, SID, MAGIRAN, and Barakat will be conducted. Following the online search, articles will be screened by two independent reviewers according to inclusion and exclusion criteria. Eligible studies will be critically appraised by reviewers at the study level for methodological quality using Joanna Briggs Institute's standardized critical appraisal tools. The extracted data from selected studies will cover the study populations, methods, current evidence about the physiological role of extracellular vesicles and exosomes in reproductive system, relevant outcomes, and possible conclusions about the effectiveness of exposure. Regarding the role of exosomes and their cargoes in the function of reproductive tract, the possible beneficial or adverse effects following exosomal administration from younger women to older women will be evaluated in the systematic review. As a result, exosome therapy could be suggested as a novel therapeutic agent if the favorable results are identified.
Sections du résumé
BACKGROUND
Exosomes may have critical roles in the maternal-embryo cross-talk for the recognition and maintenance of pregnancy during maternal aging. Exosomes have the capability to carry developmental signaling molecules with the ability to modulate gene expressions and affect growth and regulation of embryo during pregnancy. Systematic review aims to evaluate age-related alterations in the exosomal content and functions that can influence the reproductive performance in human and animal models as conveyors of senescence signals.
METHODS
A literature search of electronic databases including MEDLINE (PubMed), Embase, ProQuest, Scopus, Google Scholar, WHO, SID, MAGIRAN, and Barakat will be conducted. Following the online search, articles will be screened by two independent reviewers according to inclusion and exclusion criteria. Eligible studies will be critically appraised by reviewers at the study level for methodological quality using Joanna Briggs Institute's standardized critical appraisal tools. The extracted data from selected studies will cover the study populations, methods, current evidence about the physiological role of extracellular vesicles and exosomes in reproductive system, relevant outcomes, and possible conclusions about the effectiveness of exposure.
DISCUSSION
Regarding the role of exosomes and their cargoes in the function of reproductive tract, the possible beneficial or adverse effects following exosomal administration from younger women to older women will be evaluated in the systematic review. As a result, exosome therapy could be suggested as a novel therapeutic agent if the favorable results are identified.
Identifiants
pubmed: 31775879
doi: 10.1186/s13643-019-1228-9
pii: 10.1186/s13643-019-1228-9
pmc: PMC6882206
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
293Références
Int J Evid Based Healthc. 2015 Sep;13(3):163-9
pubmed: 26262566
Reprod Fertil Dev. 2015 Jul;27(6):897-905
pubmed: 25945781
Bioimpacts. 2017;7(3):135-137
pubmed: 29159140
Hum Reprod Update. 2016 Mar-Apr;22(2):182-93
pubmed: 26663221
Mech Ageing Dev. 2017 Dec;168:44-53
pubmed: 28259747
Ann Intern Med. 2009 Aug 18;151(4):264-9, W64
pubmed: 19622511
Exp Gerontol. 2013 Jul;48(7):626-33
pubmed: 23283304
Theriogenology. 2000 Oct 1;54(6):965-79
pubmed: 11097048
Prog Mol Biol Transl Sci. 2017;145:163-179
pubmed: 28110750
Am J Nurs. 2014 May;114(5):49-56
pubmed: 24759479
Hum Reprod Update. 2011 Nov-Dec;17(6):848-60
pubmed: 21652599
PLoS One. 2013;8(3):e58502
pubmed: 23516492
Biomed Res Int. 2015;2015:294954
pubmed: 25699269
J Assist Reprod Genet. 2016 Mar;33(3):303-311
pubmed: 26814471
Adv Pharm Bull. 2016 Sep;6(3):293-299
pubmed: 27766213
Trends Endocrinol Metab. 2010 Jan;21(1):25-32
pubmed: 19875303
Mol Hum Reprod. 2009 Jul;15(7):399-409
pubmed: 19443606
PLoS One. 2017 Mar 28;12(3):e0174535
pubmed: 28350875
Mol Aspects Med. 2018 Apr;60:92-103
pubmed: 29146100
PLoS One. 2013 Nov 14;8(11):e80181
pubmed: 24244642
Curr Environ Health Rep. 2017 Mar;4(1):30-37
pubmed: 28116555
Reproduction. 2006 Aug;132(2):191-206
pubmed: 16885529
Fertil Steril. 1996 Apr;65(4):783-90
pubmed: 8654639
Biol Reprod. 2012 Mar 19;86(3):71
pubmed: 22116803
Biophys J. 2008 Nov 1;95(9):4416-25
pubmed: 18658210
PLoS One. 2013 Nov 04;8(11):e78505
pubmed: 24223816
Trends Mol Med. 2017 Jul;23(7):636-650
pubmed: 28648185
Mol Neurobiol. 2018 Apr;55(4):3372-3393
pubmed: 28497202
Semin Reprod Med. 2009 Jan;27(1):24-31
pubmed: 19197802
Development. 2016 Sep 1;143(17):3061-73
pubmed: 27578177
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
J Clin Invest. 2016 Apr 1;126(4):1181-9
pubmed: 27035809
J Clin Invest. 2016 Apr 1;126(4):1208-15
pubmed: 27035812
Adv Drug Deliv Rev. 2013 Mar;65(3):368-75
pubmed: 22820533
Front Physiol. 2012 Jun 27;3:228
pubmed: 22754538
Sci Rep. 2017 May 2;7(1):1342
pubmed: 28465537
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
Adv Pharm Bull. 2014 Oct;4(Suppl 1):443-7
pubmed: 25364660
Leukemia. 2006 May;20(5):847-56
pubmed: 16453000
Genes (Basel). 2013 Mar 28;4(2):152-70
pubmed: 24705158
Blood Cells Mol Dis. 2005 May-Jun;34(3):214-9
pubmed: 15885604
BMC Med Res Methodol. 2003 Nov 10;3:25
pubmed: 14606960
Biofactors. 2019 May;45(3):293-303
pubmed: 30788863
Genome Biol. 2010;11(11):142
pubmed: 21122165
J Cell Mol Med. 2011 Jul;15(7):1458-73
pubmed: 20070437
Reprod Biol Endocrinol. 2016 Nov 9;14(1):78
pubmed: 27829441
Hum Reprod Update. 2008 Mar-Apr;14(2):131-42
pubmed: 18239135
Hum Reprod. 1997 Aug;12(8):1736-41
pubmed: 9308804