Myocardial Ischemic Burden and Differences in Prognosis Among Patients With and Without Diabetes: Results From the Multicenter International REFINE SPECT Registry.
Aged
Angina, Unstable
/ diagnosis
Cohort Studies
Coronary Artery Disease
/ complications
Diabetes Mellitus
/ diagnosis
Diabetic Angiopathies
/ diagnosis
Female
Humans
Male
Middle Aged
Myocardial Infarction
/ complications
Myocardial Ischemia
/ complications
Myocardial Perfusion Imaging
/ methods
Prevalence
Prognosis
Propensity Score
Registries
Risk Factors
Tomography, Emission-Computed, Single-Photon
/ methods
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
09
07
2019
accepted:
03
11
2019
pubmed:
30
11
2019
medline:
6
11
2020
entrez:
29
11
2019
Statut:
ppublish
Résumé
Prevalence and prognostic impact of cardiovascular disease differ between patients with or without diabetes. We aimed to explore differences in the prevalence and prognosis of myocardial ischemia by automated quantification of total perfusion deficit (TPD) among patients with and without diabetes. Of 20,418 individuals who underwent single-photon emission computed tomography myocardial perfusion imaging, 2,951 patients with diabetes were matched to 2,951 patients without diabetes based on risk factors using propensity score. TPD was categorized as TPD = 0%, 0% < TPD < 1%, 1% ≤ TPD < 5%, 5% ≤ TPD ≤ 10%, and TPD >10%. Major adverse cardiovascular events (MACE) were defined as a composite of all-cause mortality, myocardial infarction, unstable angina, or late revascularization. MACE risk was increased in patients with diabetes compared with patients without diabetes at each level of TPD above 0 ( For every level of TPD >0%, even a very minimal deficit of 0% < TPD < 1%, the MACE risk was higher in the patients with diabetes compared with patients without diabetes. Patients with diabetes with minimal ischemia had comparable MACE risk as patients without diabetes with significant ischemia.
Identifiants
pubmed: 31776140
pii: dc19-1360
doi: 10.2337/dc19-1360
pmc: PMC6971784
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
453-459Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL089765
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© 2019 by the American Diabetes Association.
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