WNT/RYK signaling restricts goblet cell differentiation during lung development and repair.
A549 Cells
Animals
Cell Differentiation
/ physiology
Goblet Cells
/ cytology
Humans
Hyperplasia
/ metabolism
Lung
/ cytology
Mice
Mucus
/ metabolism
Pneumonia
/ metabolism
Pulmonary Disease, Chronic Obstructive
/ metabolism
Receptor Protein-Tyrosine Kinases
/ metabolism
Wnt Signaling Pathway
/ physiology
beta Catenin
/ metabolism
COPD
RYK
WNT/β-catenin signaling
goblet cell hyperplasia
lung
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
17 12 2019
17 12 2019
Historique:
pubmed:
30
11
2019
medline:
14
4
2020
entrez:
29
11
2019
Statut:
ppublish
Résumé
Goblet cell metaplasia and mucus hypersecretion are observed in many pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. However, the regulation of goblet cell differentiation remains unclear. Here, we identify a regulator of this process in an
Identifiants
pubmed: 31776260
pii: 1911071116
doi: 10.1073/pnas.1911071116
pmc: PMC6926051
doi:
Substances chimiques
beta Catenin
0
RYK protein, human
EC 2.7.10.1
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
Ryk protein, mouse
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
25697-25706Déclaration de conflit d'intérêts
The authors declare no competing interest.
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