Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
Animals
Apoptosis Regulatory Proteins
/ metabolism
Brain
/ metabolism
Carrier Proteins
/ metabolism
Colitis
/ complications
Dexamethasone
/ pharmacology
Dextran Sulfate
Endothelial Cells
/ drug effects
Epithelial Cells
/ drug effects
Gastrointestinal Microbiome
/ drug effects
Gastrointestinal Tract
/ drug effects
Hemangioma, Cavernous, Central Nervous System
/ drug therapy
Humans
Intestinal Mucosa
/ drug effects
KRIT1 Protein
/ metabolism
Ligands
Membrane Proteins
/ metabolism
Mice
Proto-Oncogene Proteins
/ metabolism
Signal Transduction
/ drug effects
Toll-Like Receptor 4
/ metabolism
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
27 11 2019
27 11 2019
Historique:
received:
14
12
2018
revised:
17
07
2019
accepted:
09
10
2019
entrez:
29
11
2019
pubmed:
30
11
2019
medline:
12
9
2020
Statut:
ppublish
Résumé
Cerebral cavernous malformation (CCM) is a genetic, cerebrovascular disease. Familial CCM is caused by genetic mutations in
Identifiants
pubmed: 31776290
pii: 11/520/eaaw3521
doi: 10.1126/scitranslmed.aaw3521
pmc: PMC6937779
mid: NIHMS1064865
pii:
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
CCM2 protein, human
0
Carrier Proteins
0
KRIT1 Protein
0
KRIT1 protein, human
0
Ligands
0
Membrane Proteins
0
PDCD10 protein, human
0
PDCD10 protein, mouse
0
Proto-Oncogene Proteins
0
Toll-Like Receptor 4
0
Dexamethasone
7S5I7G3JQL
Dextran Sulfate
9042-14-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL094326
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS092521
Pays : United States
Organisme : NCATS NIH HHS
ID : U2C TR002818
Pays : United States
Organisme : NINDS NIH HHS
ID : F30 NS100252
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS065705
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007971
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA174432
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136507
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA229216
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100949
Pays : United States
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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