A radical exchange process: synthesis of bicyclo[1.1.1]pentane derivatives of xanthates.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
10 Dec 2019
10 Dec 2019
Historique:
pubmed:
30
11
2019
medline:
30
11
2019
entrez:
29
11
2019
Statut:
ppublish
Résumé
Bicyclo[1.1.1]pentane (BCP) replacement as a bioisostere in drug molecules has an influence on their permeability, aqueous solubility and in vitro metabolic stability. Thus, the chemical installation of the BCP unit into a chemical entity remains a significant challenge from a synthetic point of view. Here, we have presented a new approach for the installation of the BCP unit on the xanthate moiety by means of a radical exchange process.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM