Growing, evolving and sticking in a flowing environment: understanding IgA interactions with bacteria in the gut.
immunoglobulin A
microbiota
modeling
physiology
population dynamics
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
01
08
2019
revised:
13
10
2019
accepted:
14
10
2019
pubmed:
30
11
2019
medline:
6
2
2020
entrez:
29
11
2019
Statut:
ppublish
Résumé
Immunology research in the last 50 years has made huge progress in understanding the mechanisms of anti-bacterial defense of deep, normally sterile, tissues such as blood, spleen and peripheral lymph nodes. In the intestine, with its dense commensal microbiota, it seems rare that this knowledge can be simply translated. Here we put forward the idea that perhaps it is not always the theory of immunology that is lacking to explain mucosal immunity, but rather that we have overlooked crucial parts of the mucosal immunological language required for its translation: namely intestinal and bacterial physiology. We will try to explain this in the context of intestinal secretory antibodies (mainly secretory IgA), which have been described to prevent, to alter, to not affect, or to promote colonization of the intestine and gut-draining lymphoid tissues, and where effector mechanisms have remained elusive. In fact, these apparently contradictory outcomes can be generated by combining the basic premises of bacterial agglutination with an understanding of bacterial growth (i.e. secretory IgA-driven enchained growth), fluid handling and bacterial competition in the gut lumen.
Identifiants
pubmed: 31777063
doi: 10.1111/imm.13156
pmc: PMC6904610
doi:
Substances chimiques
Immunoglobulin A, Secretory
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
52-62Informations de copyright
© 2019 John Wiley & Sons Ltd.
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