Hypothalamic Kisspeptin Expression in Hyperandrogenic Female Rats and Aging Rats.
Kiss1
androgen
dopaminergic neuron
dynorphin
neurokinin B
Journal
Acta histochemica et cytochemica
ISSN: 0044-5991
Titre abrégé: Acta Histochem Cytochem
Pays: Japan
ID NLM: 0147110
Informations de publication
Date de publication:
29 Oct 2019
29 Oct 2019
Historique:
received:
22
05
2019
accepted:
05
08
2019
entrez:
29
11
2019
pubmed:
30
11
2019
medline:
30
11
2019
Statut:
ppublish
Résumé
Hypothalamic kisspeptin neurons stimulate gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) release. Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) of rats induce an LH surge for ovulation, and those in the arcuate nucleus (ARC) regulate pulsatile LH secretion for follicle development and spermatogenesis. Dysfunction of kisspeptin neurons thus reduces the reproductive function. This review focuses on the effect of androgen or aging on kisspeptin expression in rats. Although androgen directly suppresses ARC kisspeptin neurons in female rats, the AVPV kisspeptin neurons are hardly affected. In rats, plasma LH concentrations decrease in both sexes with aging, and ARC kisspeptin expression also decreases in old rats compared with young rats. In addition, kisspeptin neurons may be associated with hyperprolactinemia in old female rats because they are known to release prolactin through hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons. Hypothalamic kisspeptin neurons are thus the main regulator to secrete LH, and inhibition of kisspeptin expression leads to various kinds of reproductive dysfunction.
Identifiants
pubmed: 31777408
doi: 10.1267/ahc.19013
pii: JST.JSTAGE/ahc/19013
pmc: PMC6872488
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
85-91Informations de copyright
2019 The Japan Society of Histochemistry and Cytochemistry.
Déclaration de conflit d'intérêts
VIThere are no conflicts of interest.
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