Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair.
Amnion
/ chemistry
Animals
Cardiotonic Agents
/ administration & dosage
Cattle
Cells, Cultured
Collagen
/ analysis
Epithelial Cells
Extracellular Matrix
/ chemistry
Female
Fibrosis
/ pathology
Glycosaminoglycans
/ analysis
Humans
Hydrogels
/ administration & dosage
Injections
Materials Testing
Myocardial Infarction
/ pathology
Myocardium
/ pathology
Pregnancy
Rats, Sprague-Dawley
Tissue Engineering
/ methods
amniotic membranes
decellularization
hydrogels
myocardial infarctions
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
28
04
2019
revised:
03
10
2019
pubmed:
30
11
2019
medline:
5
3
2021
entrez:
29
11
2019
Statut:
ppublish
Résumé
Ischemic heart disease represents the leading cause of death worldwide. Heart failure following myocardial infarction (MI) is associated with severe fibrosis formation and cardiac remodeling. Recently, injectable hydrogels have emerged as a promising approach to repair the infarcted heart and improve heart function through minimally invasive administration. Here, a novel injectable human amniotic membrane (hAM) matrix is developed to enhance cardiac regeneration following MI. Human amniotic membrane is isolated from human placenta and engineered to be a thermoresponsive, injectable gel around body temperature. Ultrasound-guided injection of hAM matrix into rat MI hearts significantly improves cardiac contractility, as measured by ejection fraction (EF), and decrease fibrosis. The results of this study demonstrate the feasibility of engineering as an injectable hAM matrix and its efficacy in attenuating degenerative changes in cardiac function following MI, which may have broad applications in tissue regeneration.
Identifiants
pubmed: 31778043
doi: 10.1002/adhm.201900544
pmc: PMC6986802
mid: NIHMS1062472
doi:
Substances chimiques
Cardiotonic Agents
0
Glycosaminoglycans
0
Hydrogels
0
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900544Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL121450
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117213
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL094162
Pays : United States
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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