Antiepileptic effects of electrical stimulation of the piriform cortex.
Cerebro-cerebral evoked potentials (CCEPs)
Kainic acid (KA)
Low-frequency stimulation (LFS)
Piriform cortex (PC)
Radial arm maze (RAM)
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
10
03
2019
revised:
17
09
2019
accepted:
24
09
2019
pubmed:
30
11
2019
medline:
24
10
2020
entrez:
29
11
2019
Statut:
ppublish
Résumé
Deep brain stimulation (DBS) may help control seizures in individuals with medically intractable epilepsy who are not candidates for resective surgery. The current review focuses on some preclinical studies of DBS of the piriform cortex (PC), an area involved in the generation and maintenance of seizures, as a potential therapeutic option for refractory epilepsy. We also present findings suggesting the safety of low frequency stimulation (LFS) of the PC on memory. A variety of LFS parameters have been suggested as an effective treatment strategy for refractory epilepsy. In generalized epilepsy, however, recent studies suggest that LFS may exacerbate seizures and high frequency stimulation (HFS) might be an alternative. Hence, further studies are required to explore the potential therapeutic targets and proper stimulation parameters for the successful translation of DBS of the PC to the clinic.
Identifiants
pubmed: 31778664
pii: S0014-4886(19)30219-5
doi: 10.1016/j.expneurol.2019.113070
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113070Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure of conflicts of interest This work was supported by the George Washington University and pilot grant from Clinical and Translational Science Institute at Children's National for Mohamad Z. Koubeissi. There are no other conflicts of interest related to this work. The remaining authors have no conflict of interest.