Feedback-controlled photolytic gas phase nitric oxide delivery from S-nitrosothiol-doped silicone rubber films.

Feedback Nitric Oxide Photolysis S-Nitrosothiols Silicone Elastomers
Feedback control Inhalation NO therapy NO Nitric oxide S-nitrosothiol

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
02 2020
Historique:
received: 28 05 2019
revised: 28 10 2019
accepted: 24 11 2019
pubmed: 30 11 2019
medline: 22 6 2021
entrez: 29 11 2019
Statut: ppublish

Résumé

Constant therapeutic gas phase nitric oxide (NO) delivery is achieved from S-nitrosothiol (RSNO) type NO donor doped silicone rubber films using feedback-controlled photolysis. For photo-release of the NO gas, the intensity of the LED light source is controlled via a PID (proportional-integral-derivative) controller implemented on a microcontroller. The NO concentration within the emitted gas phase is monitored continuously with a commercial amperometric NO gas sensor. NO release was accurately adjustable up to 10 ppm across a broad range of setpoints with response times of roughly 1 min or less. When NO is generated into an air recipient stream, lower NO yields and a comparable level of toxic nitrogen dioxide (NO

Identifiants

DOI: 10.1016/j.jconrel.2019.11.030 PMID: 31778741 PMC: PMC7895313
pubmed: 31778741
pii: S0168-3659(19)30689-3
doi: 10.1016/j.jconrel.2019.11.030
pmc: PMC7895313
mid: NIHMS1668357
pii:
doi:

Substances chimiques

S-Nitrosothiols 0
Silicone Elastomers 0
Nitric Oxide 31C4KY9ESH

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

264-269

Subventions

Organisme : NIBIB NIH HHS
ID : R21 EB024038
Pays : United States

Informations de copyright

Copyright © 2019. Published by Elsevier B.V.

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Auteurs

Gergely Lautner (G)

Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

Orsolya Lautner-Csorba (O)

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

Blake Stringer (B)

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

Mark E Meyerhoff (ME)

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mmeyerho@umich.edu.

Steven P Schwendeman (SP)

Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: schwende@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Analyse des systèmes › Recherche opérationnelle › Rétroaction › Feedback-controlled photolytic gas phase...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Feedback-controlled photolytic gas phase...
questionsmedicales.fr › Phénomènes chimiques › Processus photochimiques › Photolyse › Feedback-controlled photolytic gas phase...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › S-Nitrosothiols › Feedback-controlled photolytic gas phase...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Élastomères › Siloxane élastomère › Feedback-controlled photolytic gas phase...