Toxicity, Pharmacokinetics, and Gut Microbiome of Oral Administration of Sesterterpene MHO7 Derived from a Marine Fungus.
Gut microbiome
Log P/D values
MHO7
Pharmacokinetics
Toxicity
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
26 Nov 2019
26 Nov 2019
Historique:
received:
10
10
2019
revised:
25
11
2019
accepted:
25
11
2019
entrez:
30
11
2019
pubmed:
30
11
2019
medline:
28
5
2020
Statut:
epublish
Résumé
Sesterterpene MHO7 derived from mangrove fungus is a novel estrogen receptor degrader for the treatment of breast cancer. To explore its safety and pharmacokinetics in vivo, Log P/D values, stability in simulated gastric/intestinal (SGF/SIF), toxicity, and pharmacokinetics studies were carried mainly by liquid chromatography technique coupled with tandem mass spectrometry (LC-MS/MS) method in mice, and the effect of MHO7 on mice gut microbiota at different time points was revealed by 16S rRNA sequencing. Log P/D values ranged 0.93-2.48, and the compound in SGF and SIF is stable under the concentration of 5 mM·L
Identifiants
pubmed: 31779201
pii: md17120667
doi: 10.3390/md17120667
pmc: PMC6950057
pii:
doi:
Substances chimiques
Sesterterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the National Key R&D Program of China
ID : No. 2018YFC0311005
Organisme : National Natural Science Foundation of China
ID : Grant No. 81741153
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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