Expression of miRNAs from the Imprinted
Biomarkers
Calcium-Binding Proteins
/ genetics
Cell Differentiation
/ genetics
Cell Line
Gene Expression Regulation, Developmental
Genomic Imprinting
Humans
Immunophenotyping
Iodide Peroxidase
/ genetics
Membrane Proteins
/ genetics
MicroRNAs
/ genetics
Osteogenesis
/ genetics
Pluripotent Stem Cells
/ cytology
Quantitative Trait Loci
RNA Interference
ACVR2B
human pluripotent stem cells
imprinting
microRNA
osteogenic differentiation
variability
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
26 11 2019
26 11 2019
Historique:
received:
27
08
2019
revised:
08
11
2019
accepted:
19
11
2019
entrez:
30
11
2019
pubmed:
30
11
2019
medline:
25
7
2020
Statut:
epublish
Résumé
Substantial variations in differentiation properties have been reported among human pluripotent cell lines (hPSC), which could affect their utility and clinical safety. We characterized the variable osteogenic capacity observed between different human pluripotent stem cell lines. By focusing on the miRNA expression profile, we demonstrated that the osteogenic differentiation propensity of human pluripotent stem cell lines could be associated with the methylation status and the expression of miRNAs from the imprinted
Identifiants
pubmed: 31779280
pii: cells8121523
doi: 10.3390/cells8121523
pmc: PMC6953034
pii:
doi:
Substances chimiques
Biomarkers
0
Calcium-Binding Proteins
0
DLK1 protein, human
0
Membrane Proteins
0
MicroRNAs
0
iodothyronine deiodinase type III
EC 1.11.1.-
Iodide Peroxidase
EC 1.11.1.8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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