Essential oils as topical anti-infective agents: A systematic review and meta-analysis.

Acne Vulgaris / drug therapy Anti-Infective Agents, Local / therapeutic use Humans Methicillin-Resistant Staphylococcus aureus / drug effects Oils, Volatile / therapeutic use Randomized Controlled Trials as Topic
Alternative therapy Aromatherapy Clinical trial Tea tree oil

Journal

Complementary therapies in medicine
ISSN: 1873-6963
Titre abrégé: Complement Ther Med
Pays: Scotland
ID NLM: 9308777

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 26 08 2019
revised: 27 09 2019
accepted: 17 10 2019
entrez: 30 11 2019
pubmed: 30 11 2019
medline: 11 4 2020
Statut: ppublish

Résumé

This study summarized evidence on the efficacy and safety of essential oils (EOs) in the treatment of topical infections. Systematic review of clinical trials conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline. Electronic databases of the Cochrane, PubMed, EMBASE, Web of Science, and Scopus were searched from inception to November 2018. Essential oil of any type, standard treatment and placebo. Outcomes of the study include total acne count, acne severity index, reduction in total acne surface area, number of non-inflammatory acne lesions and inflammatory acne lesions, microbial cure rate, microbial decolonization rate, and new microbial emergence. Non-significant but higher proportion of MRSA was cleared in EOs group (69% [95%CI: 34%, 96%]) compared to routine care (45% [95%CI: 36%, 53%]). Essential oils significantly lowered level of new MRSA emergence (9% [95% CI: 5%, 14%], I Essential oils could be considered as alternative treatment for acne, decolonization of MRSA, and topical fungal infections, yet the low quality and heterogeneity among the studies calls for further studies.

Identifiants

DOI: 10.1016/j.ctim.2019.102224 PMID: 31780027
pubmed: 31780027
pii: S0965-2299(19)31268-3
doi: 10.1016/j.ctim.2019.102224
pii:
doi:

Substances chimiques

Anti-Infective Agents, Local 0
Oils, Volatile 0

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102224

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Serawit Deyno (S)

Department of Pharmacology, Mbarara University of Science and Technology, Mbarara, P.O.Box 1410, Uganda; Pharm-Biotechnology and Traditional Medicine (PHARMBIOTRAC) Center of Excellence, Mbarara University of Science and Technology, Mbarara, P.O.Box 1410, Uganda; Department of Pharmacology, School of Medicine, College of Medicine and Health Sciences, Hawassa University, P. O. Box 1560, Hawassa, Ethiopia. Electronic address: dserawit@std.must.ac.ug.

Andrew G Mtewa (AG)

Pharm-Biotechnology and Traditional Medicine (PHARMBIOTRAC) Center of Excellence, Mbarara University of Science and Technology, Mbarara, P.O.Box 1410, Uganda; Chemistry Section, Department of Applied Sciences, Malawi Institute of Technology, Malawi University of Science & Technology, Limbe, Malawi; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, DD1 5 EH, Scotland, United Kingdom. Electronic address: amtewa@must.ac.mw.

Abiy Abebe (A)

Traditional and Modern Drug Research Directorate, Ethiopian Public Health Research Institute, Ethiopia. Electronic address: abiyabg@yahoo.com.

Ariya Hymete (A)

Department of Pharmaceutical chemistry and Pharmacognosy, Addis Ababa University, Ethiopia. Electronic address: hymete@yahoo.com.

Eyasu Makonnen (E)

Center for Innovative Drug Development and Therapeutic Trials for Africa, College of Health Sciences, Ethiopia. Electronic address: eyasumakonnen@yahoo.com.

Joel Bazira (J)

Department of Microbiology, Mbarara University of Science and Technology, Mbarara, P.O.Box 1410, Uganda. Electronic address: jbazira@must.ac.ug.

Paul E Alele (PE)

Department of Pharmacology, Mbarara University of Science and Technology, Mbarara, P.O.Box 1410, Uganda. Electronic address: paulalele@must.ac.ug.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies des glandes sébacées › Acné juvénile › Essential oils as topical anti-infective...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Anti-infectieux locaux › Essential oils as topical anti-infective...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Essential oils as topical anti-infective...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Essential oils as topical anti-infective...
questionsmedicales.fr › Lipides › Huiles › Huile essentielle › Essential oils as topical anti-infective...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Essential oils as topical anti-infective...