Pre-treatment With Fasudil Prevents Neomycin-Induced Hair Cell Damage by Reducing the Accumulation of Reactive Oxygen Species.
aminoglycoside
fasudil
hair cell
ototoxic
reactive oxygen species
rho signaling pathway
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
07
2019
accepted:
16
10
2019
entrez:
30
11
2019
pubmed:
30
11
2019
medline:
30
11
2019
Statut:
epublish
Résumé
Ototoxic drug-induced hair cell (HC) damage is one of the main causes of sensorineural hearing loss, which is one of the most common sensory disorders in humans. Aminoglycoside antibiotics are common ototoxic drugs, and these can cause the accumulation of intracellular oxygen free radicals and lead to apoptosis in HCs. Fasudil is a Rho kinase inhibitor and vasodilator that has been widely used in the clinic and has been shown to have neuroprotective effects. However, the possible application of fasudil in protecting against aminoglycoside-induced HC loss and hearing loss has not been investigated. In this study, we investigated the ability of fasudil to protect against neomycin-induced HC loss both
Identifiants
pubmed: 31780893
doi: 10.3389/fnmol.2019.00264
pmc: PMC6851027
doi:
Types de publication
Journal Article
Langues
eng
Pagination
264Informations de copyright
Copyright © 2019 Zhang, Li, He, Wang, Shao, Cheng, Zhang, Tang, Qian, Kong, Wang, Chai and Gao.
Références
Int J Mol Sci. 2012;13(7):8293-8307
pubmed: 22942703
Front Cell Neurosci. 2018 May 23;12:139
pubmed: 29875633
Expert Opin Investig Drugs. 2005 Sep;14(9):1157-9
pubmed: 16144499
Cardiovasc Res. 2016 May 1;110(1):140-50
pubmed: 26825552
Biomed Pharmacother. 2014 Apr;68(3):267-75
pubmed: 24406296
No To Shinkei. 1993 Sep;45(9):819-24
pubmed: 8217408
Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L667-74
pubmed: 21856816
Cell Death Dis. 2016 Mar 10;7:e2136
pubmed: 26962686
Expert Opin Ther Targets. 2012 Apr;16(4):355-63
pubmed: 22449260
Oncotarget. 2016 Oct 11;7(41):66647-66659
pubmed: 27556499
Front Cell Neurosci. 2014 Sep 15;8:248
pubmed: 25278835
J Cell Mol Med. 2018 Feb;22(2):1056-1069
pubmed: 29119680
Behav Neurosci. 2009 Feb;123(1):218-23
pubmed: 19170447
Int J Pediatr Otorhinolaryngol. 2014 Dec;78(12):2198-204
pubmed: 25458160
Int J Antimicrob Agents. 2009 Mar;33(3):201-5
pubmed: 18976888
J Assoc Res Otolaryngol. 2013 Oct;14(5):645-59
pubmed: 23821348
J Physiol. 2005 Sep 1;567(Pt 2):505-21
pubmed: 15994187
Aging (Albany NY). 2015 Aug;7(8):579-94
pubmed: 26319214
J Perinatol. 2013 Jan;33(1):3-8
pubmed: 22878560
N Engl J Med. 1993 Oct 7;329(15):1092-102
pubmed: 8371732
Biochem Biophys Res Commun. 2015 Aug 28;464(3):794-9
pubmed: 26187664
Sci Rep. 2017 Jan 23;7:41094
pubmed: 28112219
Sci Rep. 2016 Jul 13;6:29621
pubmed: 27405449
J Cell Sci. 2008 Sep 1;121(Pt 17):2871-9
pubmed: 18682499
Stroke. 2005 Oct;36(10):2251-7
pubmed: 16141422
Sci Rep. 2015 Feb 02;5:8181
pubmed: 25640330
Sci Rep. 2017 Jun 14;7(1):3506
pubmed: 28615657
Circ J. 2009 Sep;73(9):1731-9
pubmed: 19590140
Future Cardiol. 2011 Sep;7(5):657-71
pubmed: 21929346
Int J Dev Neurosci. 2000 Apr-Jun;18(2-3):259-70
pubmed: 10715580
Ann N Y Acad Sci. 1999 Nov 28;884:389-409
pubmed: 10842609
Hear Res. 2006 Nov;221(1-2):128-35
pubmed: 17005344
Toxicol In Vitro. 2013 Mar;27(2):954-63
pubmed: 23357416
Biol Chem. 2013 Nov;394(11):1399-410
pubmed: 23950574
Autophagy. 2017;13(11):1884-1904
pubmed: 28968134
Am J Otol. 2000 Mar;21(2):161-7
pubmed: 10733178
Pulm Pharmacol Ther. 2017 Oct;46:54-63
pubmed: 28782712
Mol Cell. 2012 Oct 26;48(2):158-67
pubmed: 23102266
J Biol Chem. 2007 Feb 2;282(5):2871-9
pubmed: 17132626
J Immunol. 2009 Feb 15;182(4):2385-94
pubmed: 19201893
Drug Deliv. 2018 Nov;25(1):1033-1043
pubmed: 30799660
Curr Med Chem. 2011;18(31):4866-71
pubmed: 21919841
Exp Cell Res. 2006 Jan 1;312(1):5-15
pubmed: 16259978
Hear Res. 1989 Feb;37(3):203-17
pubmed: 2468634
J Clin Invest. 2016 Sep 1;126(9):3556-66
pubmed: 27500493
Cell Death Differ. 2012 Jun;19(6):968-79
pubmed: 22139133
Neuroscience. 2016 Oct 1;333:204-13
pubmed: 27457035
Cell. 2005 Feb 25;120(4):483-95
pubmed: 15734681
J Biol Chem. 2005 Oct 28;280(43):36273-82
pubmed: 16118208
Rev Esp Cardiol. 2005 May;58(5):523-66
pubmed: 15899198
Cell Death Dis. 2015 Jan 22;6:e1605
pubmed: 25611380
Antioxid Redox Signal. 2019 Apr 10;30(11):1389-1410
pubmed: 29587485