Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence?
P2Y12 inhibitors
aspirin
atherothrombosis
microvesicles
platelets
thromboxane
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
07
2019
accepted:
30
09
2019
entrez:
30
11
2019
pubmed:
30
11
2019
medline:
30
11
2019
Statut:
epublish
Résumé
Platelet-derived large extracellular vesicles (often referred to as microparticles in the field of cardiovascular disease) have been identified as effector in the atherothrombotic process, therefore representing a target of pharmacological intervention of potential interest. Despite that, limited evidence is so far available concerning the effects of antiplatelet agents on the release of platelet-derived extracellular vesicles. In the present narrative review, the mechanisms leading to vesiculation in platelets and the pathophysiological processes implicated will be discussed. This will be followed by a summary of the present evidence concerning the effects of antiplatelet agents under experimental conditions and in clinical settings.
Identifiants
pubmed: 31780927
doi: 10.3389/fphar.2019.01256
pmc: PMC6857039
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1256Informations de copyright
Copyright © 2019 Taus, Meneguzzi, Castelli and Minuz.
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