Apolipoprotein E Deficiency Causes Endothelial Dysfunction in the Mouse Retina.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
06
2019
revised:
25
09
2019
accepted:
16
10
2019
entrez:
30
11
2019
pubmed:
30
11
2019
medline:
21
4
2020
Statut:
epublish
Résumé
Atherogenic lipoproteins may impair vascular reactivity consecutively causing tissue damage in multiple organs via abnormal perfusion and excessive reactive oxygen species generation. We tested the hypothesis that chronic hypercholesterolemia causes endothelial dysfunction and cell loss in the retina. Twelve-month-old apolipoprotein E-deficient (ApoE-/-) mice and age-matched wild-type controls were used in this study ( Responses to the endothelium-dependent vasodilator, acetylcholine, were markedly impaired in retinal arterioles of ApoE-/- mice ( Apolipoprotein E deficiency induces oxidative stress and endothelial dysfunction in retinal arterioles, which may trigger hypoxia in the retinal tissue. Oxidative stress in nonvascular retinal tissue appears to be prevented by the upregulation of antioxidant redox enzymes, resulting in neuron preservation.
Identifiants
pubmed: 31781340
doi: 10.1155/2019/5181429
pmc: PMC6875001
doi:
Substances chimiques
Apolipoproteins E
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5181429Informations de copyright
Copyright © 2019 Jenia Kouchek Zadeh et al.
Déclaration de conflit d'intérêts
The authors state that there is no conflict of interests.
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