Filaggrin gene mutations in relation to contact allergy and hand eczema in adolescence.
adolescent
contact allergy
dry skin
epidemiology
filaggrin
fragrance
hand eczema
nickel
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
28
08
2019
revised:
21
11
2019
accepted:
27
11
2019
pubmed:
30
11
2019
medline:
24
11
2020
entrez:
30
11
2019
Statut:
ppublish
Résumé
Filaggrin is an important protein for structure and function of the skin barrier. Filaggrin gene (FLG) mutations are known to result in dry skin, impaired skin barrier, and increased risk for atopic dermatitis. However, it is not clear whether these mutations are associated with contact allergy or hand eczema in adolescence. The purpose of this study was to investigate whether FLG mutations are associated with contact allergy, self-reported hand eczema, or dry skin in adolescence. We used data from the 16-year follow-up in the BAMSE cohort, information obtained from a Web-based questionnaire including questions on hand eczema and dry skin, from FLG mutation analysis (R501X, R2447X, 2282del4), and patch testing (n = 1822). Logistic regression analyses showed no statistically significant associations between FLG mutations and contact allergy (any contact allergy, nickel allergy, or fragrance allergy) according to patch test, or self-reported hand eczema at 16 years, or hand eczema ever. However, FLG mutations were associated with self-reported dry skin at 16 years. FLG mutations are associated with self-reported dry skin at 16 years. However, in this study no consistent associations were found between FLG mutations and contact allergy or hand eczema at 16.
Sections du résumé
BACKGROUND
BACKGROUND
Filaggrin is an important protein for structure and function of the skin barrier. Filaggrin gene (FLG) mutations are known to result in dry skin, impaired skin barrier, and increased risk for atopic dermatitis. However, it is not clear whether these mutations are associated with contact allergy or hand eczema in adolescence.
OBJECTIVES
OBJECTIVE
The purpose of this study was to investigate whether FLG mutations are associated with contact allergy, self-reported hand eczema, or dry skin in adolescence.
METHODS
METHODS
We used data from the 16-year follow-up in the BAMSE cohort, information obtained from a Web-based questionnaire including questions on hand eczema and dry skin, from FLG mutation analysis (R501X, R2447X, 2282del4), and patch testing (n = 1822).
RESULTS
RESULTS
Logistic regression analyses showed no statistically significant associations between FLG mutations and contact allergy (any contact allergy, nickel allergy, or fragrance allergy) according to patch test, or self-reported hand eczema at 16 years, or hand eczema ever. However, FLG mutations were associated with self-reported dry skin at 16 years.
CONCLUSIONS
CONCLUSIONS
FLG mutations are associated with self-reported dry skin at 16 years. However, in this study no consistent associations were found between FLG mutations and contact allergy or hand eczema at 16.
Substances chimiques
FLG protein, human
0
Filaggrin Proteins
0
Perfume
0
S100 Proteins
0
Nickel
7OV03QG267
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
147-152Subventions
Organisme : AFA Försäkring
Organisme : Astma- och Allergiförbundet
Organisme : Forskningsrådet om Hälsa, Arbetsliv och Välfärd
Organisme : Karolinska Institutet
Organisme : Seventh Framework Programme
ID : 29 Programme MeDALL grant agreement 261357
Organisme : Region Stockholms
Organisme : Vetenskapsrådet
Organisme : Welander-Finsen Foundation
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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