Endothelial EphB4 maintains vascular integrity and transport function in adult heart.
Adult
Animals
Cell Adhesion
/ genetics
Cell Differentiation
/ genetics
Embryonic Development
/ genetics
Endothelial Cells
/ metabolism
Endothelium, Vascular
/ growth & development
Ephrin-B2
/ genetics
Heart
/ growth & development
Homeostasis
/ genetics
Humans
Ligands
Mice
Morphogenesis
/ genetics
Muscle, Skeletal
/ growth & development
Neovascularization, Physiologic
/ genetics
Receptor, EphB4
/ genetics
blood vessel
cardiomyocyte
developmental biology
endothelial cell
heart
homeostasis
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
29 11 2019
29 11 2019
Historique:
received:
06
02
2019
accepted:
15
11
2019
entrez:
30
11
2019
pubmed:
30
11
2019
medline:
13
5
2020
Statut:
epublish
Résumé
The homeostasis of heart and other organs relies on the appropriate provision of nutrients and functional specialization of the local vasculature. Here, we have used mouse genetics, imaging and cell biology approaches to investigate how homeostasis in the adult heart is controlled by endothelial EphB4 and its ligand ephrin-B2, which are known regulators of vascular morphogenesis and arteriovenous differentiation during development. We show that inducible and endothelial cell-specific inactivation of
Identifiants
pubmed: 31782728
doi: 10.7554/eLife.45863
pii: 45863
pmc: PMC6884395
doi:
pii:
Substances chimiques
EFNB2 protein, mouse
0
Ephrin-B2
0
Ligands
0
Ephb4 protein, mouse
EC 2.7.10.1
Receptor, EphB4
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Max-Planck-Gesellschaft
ID : Open-access funding (CRC 1348)
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 1348 and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM)
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : Cells-in-Motion Cluster of Excellence (EXC 1003-CiM) - Pilot Project PP-2015-12
Pays : International
Organisme : EMBO
ID : Postdoctoral fellowship - ALTF 421-2014
Pays : International
Informations de copyright
© 2019, Luxán et al.
Déclaration de conflit d'intérêts
GL, JS, ND, KK, SM, AA, FB, NN, HD, DZ, CF, HS, SH, JV, MP, RA No competing interests declared, JW is affiliated with AstraZeneca. The author has no financial interests to declare.
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