Hallmarks of postoperative liver regeneration: An updated insight on the regulatory mechanisms.
Cell Proliferation
Digestive System Surgical Procedures
Extracellular Matrix
/ metabolism
Hepatocytes
/ physiology
Humans
Kupffer Cells
/ physiology
Liver
/ cytology
Liver Regeneration
/ physiology
Neovascularization, Physiologic
Parenchymal Tissue
/ cytology
Postoperative Period
Stem Cells
/ physiology
Kupffer cell
angiogenesis
extracellular matrix
hepatic progenitor cell
liver regeneration
Journal
Journal of gastroenterology and hepatology
ISSN: 1440-1746
Titre abrégé: J Gastroenterol Hepatol
Pays: Australia
ID NLM: 8607909
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
25
10
2019
revised:
14
11
2019
accepted:
26
11
2019
pubmed:
30
11
2019
medline:
28
10
2020
entrez:
30
11
2019
Statut:
ppublish
Résumé
Performance and advances in liver surgery makes remarkable progress of the understanding of liver regeneration. Liver regeneration after liver resection has been widely researched, and the underlying mechanism mostly concerns proliferation of hepatocytes and the influence by inflammation through activation of Kupffer cells and the other parenchymal cells, the second regenerative pathway by hepatic progenitor cells (HPCs), inducing angiogenesis, remodeling of a extracellular matrix (ECM), and termination mechanisms. New clinical surgeries and the updated multiomics analysis are exploiting the remarkable progress, especially in immune regulation and metabolic process of two emerging hallmarks. This review briefly represents a systemic outline of eight hallmarks, including hepatocyte proliferation, contribution of hepatic progenitor cells, inducing angiogenesis, reprogramming of the extracellular matrix, apoptosis and termination of proliferation, inflammation, immune and metabolic regulation, which are set as organizing characteristics of postoperative liver regeneration and future directions of refining treatment targets.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
960-966Subventions
Organisme : The Medical Science and Technology Program of Henan Province China
ID : No. SBGJ2018023
Informations de copyright
© 2019 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
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