CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening.
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
23
08
2019
revised:
28
10
2019
accepted:
20
11
2019
pubmed:
30
11
2019
medline:
1
5
2021
entrez:
30
11
2019
Statut:
ppublish
Résumé
The paradigm of central nervous system (CNS) drug discovery has mostly relied on traditional approaches of rodent models or cell-based in vitro models. Owing to the issues of species differences between humans and rodents, it is difficult to correlate the robustness of data for neurodevelopmental studies. With advances in the stem-cell field, 3D CNS organoids have been developed and explored owing to their resemblance to the human brain architecture and functions. Further, CNS organoids provide a unique opportunity to mimic the human brain physiology and serve as a modeling tool to study the normal versus pathological brain or the elucidation of mechanisms of neurological disorders. Here, we discuss the recent application of a CNS organoid explored for neurodevelopment disease or a screening tool for CNS drug development.
Identifiants
pubmed: 31783130
pii: S1359-6446(19)30452-0
doi: 10.1016/j.drudis.2019.11.010
pmc: PMC7039749
mid: NIHMS1547143
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
456-465Subventions
Organisme : NIDA NIH HHS
ID : R03 DA044877
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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