Adenosine Receptor Profiling Reveals an Association between the Presence of Spare Receptors and Cardiovascular Disorders.
adenosine
adenosinergic system
cardiovascular disorders
coronary artery disease
receptor reserve
spare receptor
syncope
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Nov 2019
27 Nov 2019
Historique:
received:
24
10
2019
revised:
19
11
2019
accepted:
21
11
2019
entrez:
1
12
2019
pubmed:
1
12
2019
medline:
16
4
2020
Statut:
epublish
Résumé
Adenosine and its receptors exert a potent control on the cardiovascular system. This review aims to present emerging experimental evidence supporting the existence and implication in cardiovascular disorders of specific adenosinergic pharmacological profiles, conforming to the concept of "receptor reserve", also known as "spare receptors". This kind of receptors allow agonists to achieve their maximal effect without occupying all of the relevant cell receptors. In the cardiovascular system, spare adenosine receptors appear to compensate for a low extracellular adenosine level and/or a low adenosine receptor number, such as in coronary artery disease or some kinds of neurocardiogenic syncopes. In both cases, the presence of spare receptors appears to be an attempt to overcome a weak interaction between adenosine and its receptors. The identification of adenosine spare receptors in cardiovascular disorders may be helpful for diagnostic purposes.
Identifiants
pubmed: 31783510
pii: ijms20235964
doi: 10.3390/ijms20235964
pmc: PMC6928742
pii:
doi:
Substances chimiques
Receptors, Purinergic P1
0
Adenosine
K72T3FS567
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bristol-Myers Squibb
ID : PagaF13015
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