Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis.

E-Selectin Epidemiology ICAM3 P-Selectin Type 2 Diabetes thrombomodulin vascular injury biomarkers

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
27 Nov 2019
Historique:
received: 28 10 2019
revised: 18 11 2019
accepted: 25 11 2019
entrez: 1 12 2019
pubmed: 1 12 2019
medline: 1 12 2019
Statut: epublish

Résumé

Data on biomarkers of vascular injury and type 2 diabetes (T2D) risk from prospective studies are lacking. We evaluated seven biomarkers of vascular injury in relation to T2D. Additionally, a meta-analysis was performed. From the EPIC-Heidelberg cohort, 2224 participants were followed-up from baseline for 16 (median) years. E-Selectin, P-Selectin, intercellular adhesion molecule 3 (ICAM3), thrombomodulin, thrombopoietin, glycoprotein IIb/IIIa and fibrinogen levels were measured in baseline blood samples. The systematic review and meta-analysis included prospective studies identified through MEDLINE and Web of Science that investigated the association between mentioned biomarkers and T2D. The study population included 55% women, median age was 50 years, and 163 developed T2D. ICAM3 was associated with lower T2D risk (fully adjusted HR

Identifiants

pubmed: 31783601
pii: jcm8122075
doi: 10.3390/jcm8122075
pmc: PMC6947572
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : World Cancer Research Fund
ID : 2015/1418

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Auteurs

Laura Pletsch-Borba (L)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
Faculty of Medicine, University Medicine Heidelberg, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany.

Cora Watzinger (C)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Renée Turzanski Fortner (R)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Verena Katzke (V)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Lukas Schwingshackl (L)

Institute for Evidence in Medicine, Medical Center - University of Freiburg, Breisacher Straße 153, 79110 Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Breisacher Straße 153, 79110 Freiburg, Germany.

Solomon A Sowah (SA)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
Faculty of Medicine, University Medicine Heidelberg, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany.

Anika Hüsing (A)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Theron Johnson (T)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Marie-Luise Groß (ML)

Department of Preventive Oncology, National Centre for Tumor Diseases, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.

Sandra González Maldonado (S)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Michael Hoffmeister (M)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Peter Bugert (P)

Institute of Transfusion Medicine and Immunology, University Medicine Heidelberg, Friedrich-Ebert-Straße 107, 68167 Mannheim, Germany.
German Red Cross Blood Service Baden-Württemberg-Hessen, Friedrich-Ebert-Straße 107, D-68167 Mannheim, Germany.

Rudolf Kaaks (R)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Mirja Grafetstätter (M)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
Faculty of Medicine, University Medicine Heidelberg, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany.

Tilman Kühn (T)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

Classifications MeSH