Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review.
biomarkers
childhood obesity
miRNAs
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
27 Nov 2019
27 Nov 2019
Historique:
received:
21
10
2019
revised:
11
11
2019
accepted:
25
11
2019
entrez:
1
12
2019
pubmed:
1
12
2019
medline:
12
5
2020
Statut:
epublish
Résumé
Early detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142-3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions.
Identifiants
pubmed: 31783635
pii: nu11122890
doi: 10.3390/nu11122890
pmc: PMC6950354
pii:
doi:
Substances chimiques
Biomarkers
0
MIRN142 microRNA, human
0
MIRN143 microRNA, human
0
MIRN222 microRNA, human
0
MicroRNAs
0
Mirn140 microRNA, human
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Références
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