Stem Cells in Cardiovascular Medicine: Historical Overview and Future Prospects.
ESC
PSC
cardiovascular disease
iPSC
regeneration
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
27 11 2019
27 11 2019
Historique:
received:
22
10
2019
revised:
19
11
2019
accepted:
23
11
2019
entrez:
1
12
2019
pubmed:
1
12
2019
medline:
10
9
2020
Statut:
epublish
Résumé
Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a low regenerative capacity, leading to a loss of cardiomyocytes and persistent tissue scaring, which entails a morbid pathologic sequela. Novel therapeutic approaches are urgently needed. Stem cells, such as induced pluripotent stem cells or embryonic stem cells, exhibit great potential for cell-replacement therapy and an excellent tool for disease modeling, as well as pharmaceutical screening of novel drugs and their cardiac side effects. This review article covers not only the origin of stem cells but tries to summarize their translational potential, as well as potential risks and clinical translation.
Identifiants
pubmed: 31783680
pii: cells8121530
doi: 10.3390/cells8121530
pmc: PMC6952821
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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