Proteomic analysis of Nrk gene-disrupted placental tissue cells explains physiological significance of NRK.
Breast tumor
Dystocia
Placenta
Placentomegaly
Protein kinase
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
29 Nov 2019
29 Nov 2019
Historique:
received:
05
10
2019
accepted:
21
11
2019
entrez:
1
12
2019
pubmed:
1
12
2019
medline:
18
4
2020
Statut:
epublish
Résumé
NRK is a unique X chromosome-linked protein kinase expressed predominantly in placenta. The gene knockout causes placental overgrowth and delayed labor of Nrk-null fetuses from dams in mouse. To clarify unknown mechanisms behind the Nrk-null phenotypes, protein expression profiles were analyzed in the Nrk-null placenta using a high-performance two-dimensional electrophoresis methodology. Among around 1800 spots detected, we characterized a dozen protein spots whose expression levels were significantly altered in the Nrk-null placenta compared to wild-type. Analyzing these data sets is expected to reflect the difference physiologically in the presence or absence of NRK, facilitating the development of therapeutic strategies.
Identifiants
pubmed: 31783915
doi: 10.1186/s13104-019-4818-7
pii: 10.1186/s13104-019-4818-7
pmc: PMC6884884
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Nik related kinase
EC 2.7.1.11
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
785Subventions
Organisme : Grants-in-aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan
ID : 15K14378
Organisme : Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (CN)
ID : 21113505
Références
PLoS One. 2019 Mar 19;14(3):e0213947
pubmed: 30889197
PLoS One. 2012;7(4):e34862
pubmed: 22529944
Cold Spring Harb Perspect Med. 2015 Sep 03;5(11):null
pubmed: 26337112
Best Pract Res Clin Obstet Gynaecol. 2018 Oct;52:33-47
pubmed: 30007778
PLoS One. 2015 Oct 02;10(10):e0139750
pubmed: 26431040
Proteomics. 2005 Mar;5(4):1024-32
pubmed: 15712240
Sci Rep. 2018 Nov 13;8(1):16725
pubmed: 30425303
Science. 2000 Sep 15;289(5486):1942-6
pubmed: 10988076
Nature. 1997 Dec 11;390(6660):618-22
pubmed: 9403692
Am J Pathol. 2016 Oct;186(10):2751-60
pubmed: 27634343
Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9759-64
pubmed: 10944235
Mech Dev. 1999 Dec;89(1-2):155-9
pubmed: 10559491
Endocrinology. 2018 Jan 1;159(1):490-505
pubmed: 29029054
J Biol Chem. 2000 Jul 7;275(27):20533-9
pubmed: 10801798
J Biol Chem. 2011 Aug 19;286(33):28802-10
pubmed: 21715335
Int J Mol Sci. 2018 Jun 15;19(6):null
pubmed: 29914106
Anal Cell Pathol (Amst). 2016;2016:4131403
pubmed: 27995049
Clin Rev Allergy Immunol. 2013 Oct;45(2):267-80
pubmed: 23325331
Mol Cell Biol. 2016 Jul 14;36(15):2078-88
pubmed: 27215381
Mol Endocrinol. 2008 Jan;22(1):105-12
pubmed: 17872381
Oncotarget. 2016 Apr 12;7(15):19265-71
pubmed: 26992230
J Cell Sci. 2012 Jan 1;125(Pt 1):92-107
pubmed: 22266906
Tumour Biol. 2017 Oct;39(10):1010428317726184
pubmed: 29022497
Science. 1997 Aug 1;277(5326):681-3
pubmed: 9235889