miR302a and 122 are deregulated in small extracellular vesicles from ARPE-19 cells cultured with H
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 11 2019
29 11 2019
Historique:
received:
12
03
2019
accepted:
14
11
2019
entrez:
1
12
2019
pubmed:
1
12
2019
medline:
11
11
2020
Statut:
epublish
Résumé
Age related macular degeneration (AMD) is a common retina-related disease leading to blindness. Little is known on the origin of the disease, but it is well documented that oxidative stress generated in the retinal pigment epithelium and choroid neovascularization are closely involved. The study of circulating miRNAs is opening new possibilities in terms of diagnosis and therapeutics. miRNAs can travel associated to lipoproteins or inside small Extracellular Vesicles (sEVs). A number of reports indicate a significant deregulation of circulating miRNAs in AMD and experimental approaches, but it is unclear whether sEVs present a significant miRNA cargo. The present work studies miRNA expression changes in sEVs released from ARPE-19 cells under oxidative conditions (i.e. hydrogen peroxide, H
Identifiants
pubmed: 31784665
doi: 10.1038/s41598-019-54373-x
pii: 10.1038/s41598-019-54373-x
pmc: PMC6884596
doi:
Substances chimiques
MIRN122 microRNA, human
0
MIRN302A microRNA, human
0
MicroRNAs
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17954Références
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