Using Cumulative Load to Explain How Body Mass Index and Daily Walking Relate to Worsening Knee Cartilage Damage Over Two Years: The MOST Study.
Aged
Biomechanical Phenomena
Body Mass Index
Cartilage, Articular
/ diagnostic imaging
Disease Progression
Female
Humans
Knee Joint
/ diagnostic imaging
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Osteoarthritis, Knee
/ diagnostic imaging
Patellofemoral Joint
/ pathology
Prospective Studies
Time Factors
Walking
/ physiology
Weight-Bearing
/ physiology
Journal
Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
Titre abrégé: Arthritis Rheumatol
Pays: United States
ID NLM: 101623795
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
10
07
2019
accepted:
26
11
2019
pubmed:
1
12
2019
medline:
23
7
2020
entrez:
1
12
2019
Statut:
ppublish
Résumé
Knee cartilage damage is often linked to mechanical overloading. However, cartilage requires mechanical load to remain healthy, suggesting that underloading may be detrimental. This study was undertaken to examine knee overloading and underloading by defining cumulative load as the joint effects of body mass index (BMI) and daily walking, and examine the relationship between cumulative load and worsening cartilage damage over 2 years. We used data from the Multicenter Osteoarthritis Study. Steps/day, measured by accelerometry, and BMI were calculated at the 60-month visit. Cartilage damage on magnetic resonance imaging was semiquantitatively scored using the Whole-Organ Magnetic Resonance Imaging Score (WORMS) at the 60-month and 84-month visits; worsening damage was defined as increased WORMS between visits. Risk ratios (RRs) and 95% confidence intervals (95% CIs) were calculated using binomial regression, with adjustment for potential confounders. Our study included 964 participants, 62% of whom were female, with a mean ± SD age of 66.9 ± 7.5 years. Participants had a mean ± SD BMI of 29.7 ± 4.8 kg/m This study provides preliminary evidence that both overloading and underloading may be detrimental to medial TF cartilage, and underloading may be detrimental to lateral PF cartilage.
Identifiants
pubmed: 31785075
doi: 10.1002/art.41181
pmc: PMC8020569
mid: NIHMS1062434
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
957-965Subventions
Organisme : NIH HHS
ID : OT2 OD026548
Pays : United States
Organisme : NIAMS NIH HHS
ID : K24 AR070892
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR062506
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG018947
Pays : United States
Organisme : NIAMS NIH HHS
ID : P60 AR047785
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007490
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG018832
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK057008
Pays : United States
Organisme : NIAMS NIH HHS
ID : F32 AR073090
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG019069
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG018820
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104941
Pays : United States
Organisme : NIAMS NIH HHS
ID : K23 AR070913
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM103333
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR072571
Pays : United States
Informations de copyright
© 2019, American College of Rheumatology.
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