Circulating ensembles of tumor-associated cells: A redoubtable new systemic hallmark of cancer.
cancer related thrombosis
circulating metastatic disease
circulating tumor cell clusters
circulating tumor cells
circulating tumor emboli
circulating tumor-associated cells
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
30
08
2019
revised:
13
11
2019
accepted:
25
11
2019
pubmed:
1
12
2019
medline:
9
3
2021
entrez:
1
12
2019
Statut:
ppublish
Résumé
Circulating ensembles of tumor-associated cells (C-ETACs) which comprise tumor emboli, immune cells and fibroblasts pose well-recognized risks of thrombosis and aggressive metastasis. However, the detection, prevalence and characterization of C-ETACs have been impaired due to methodological difficulties. Our findings show extensive pan-cancer prevalence of C-ETACs on a hitherto unreported scale in cancer patients and virtual undetectability in asymptomatic individuals. Peripheral blood mononuclear cells (PBMCs) were isolated from blood samples of 16,134 subjects including 5,509 patients with epithelial malignancies in various organs and 10,625 asymptomatic individuals with age related higher cancer risk. PBMCs were treated with stabilizing reagents to protect and harvest apoptosis-resistant C-ETACs, which are defined as cell clusters comprising at least three EpCAM
Identifiants
pubmed: 31785151
doi: 10.1002/ijc.32815
pmc: PMC7217040
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
3485-3494Informations de copyright
© 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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