Tumor budding as a prognostic factor in pancreatic ductal adenocarcinoma.
PDAC
Pancreatic cancer
Pancreatic surgery
Perineural invasion
Prognostic markers
Tumor budding
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
23
05
2019
accepted:
11
11
2019
revised:
20
10
2019
pubmed:
2
12
2019
medline:
25
4
2020
entrez:
2
12
2019
Statut:
ppublish
Résumé
In this retrospective study, we analyzed the association between tumor budding and perineural invasion as well as their prognostic role in pancreatic ductal adenocarcinoma. A total of N = 119 patients resected for pancreatic ductal carcinoma from 1996 to 2015 were included. Clinical and standard histopathological parameters were retrieved from the patient's records. One representative hematoxylin and eosin section from the tumor region was examined for perineural invasion and tumor budding using light microscopy. Tumor budding was assessed independently using two different methods: in the first approach, the number of buds was counted over three fields of 0.237 mm
Identifiants
pubmed: 31786688
doi: 10.1007/s00428-019-02719-1
pii: 10.1007/s00428-019-02719-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
561-568Références
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