Decreased bone mineral density and osteoporotic fractures are associated with the development of echogenic plaques in the carotid arteries over a 10-year follow-up period: The Japanese Population-based Osteoporosis (JPOS) Cohort Study.
Adult
Aged
Aged, 80 and over
Bone Density
Cardiovascular Diseases
/ complications
Carotid Arteries
/ diagnostic imaging
Female
Follow-Up Studies
Humans
Hypertension
/ complications
Incidence
Japan
/ epidemiology
Longitudinal Studies
Middle Aged
Osteoporosis
/ complications
Osteoporotic Fractures
/ complications
Plaque, Atherosclerotic
/ complications
Prospective Studies
Risk Factors
Spine
/ pathology
Atherosclerosis
Bone mineral density
Cohort study
Echogenic carotid plaque
Osteoporotic fracture
Journal
Maturitas
ISSN: 1873-4111
Titre abrégé: Maturitas
Pays: Ireland
ID NLM: 7807333
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
16
07
2019
revised:
28
09
2019
accepted:
13
10
2019
entrez:
3
12
2019
pubmed:
4
12
2019
medline:
18
3
2020
Statut:
ppublish
Résumé
To investigate whether low bone mineral density (BMD) and history of fracture at baseline are associated with the development of echogenic carotid plaques over a 10-year follow-up period. A prospective cohort study. Development of echogenic plaques identified by ultrasonography of the carotid arteries. Among 1048 women aged 40 or more who completed the baseline survey of the Japanese Population-based Osteoporosis (JPOS) cohort study, 500 women who completed the first decade of follow-up and 267 women who completed the second decade of follow-up were included. We identified history and incidence of clinical osteoporotic fracture during the follow-up through medical interviews, and determined vertebral fractures by morphometry of absorptiometric images. We identified 67 (13.4%) and 31 (11.6%) women with echogenic plaques at the end of first and second decade of follow-up, respectively. Participants with echogenic plaques were significantly older, exhibited lower spine BMD, and had a higher prevalence of osteoporotic fracture, diabetes, and hypertension. A generalized estimating equation analysis was used to combine the participants from the two follow-up periods into a single cohort, and showed that osteoporotic BMD and osteoporotic fractures were significantly associated with the development of echogenic plaques, after adjusting for atherosclerosis risk factors (odds ratio (OR): 2.15, 95% confidence interval (95% CI): 1.04, 4.44; OR: 1.84, 95% CI: 1.03, 3.28, respectively). Osteoporotic BMD and osteoporotic fracture history were significantly, and independently, associated with an increased occurrence of echogenic plaques. Ultrasonographic screening of the carotid artery may benefit patients with osteoporosis.
Identifiants
pubmed: 31787146
pii: S0378-5122(19)30653-X
doi: 10.1016/j.maturitas.2019.10.010
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
40-47Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.