Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation.
disseminated intravascular coagulation
dog
microparticle
procoagulant activity
tissue factor
Journal
The Journal of veterinary medical science
ISSN: 1347-7439
Titre abrégé: J Vet Med Sci
Pays: Japan
ID NLM: 9105360
Informations de publication
Date de publication:
17 Jan 2020
17 Jan 2020
Historique:
pubmed:
4
12
2019
medline:
19
8
2020
entrez:
3
12
2019
Statut:
ppublish
Résumé
Microparticle (MP)-associated tissue factor (TF) activity in plasma might play a role in human disseminated intravascular coagulation (DIC). The aim of this study was to compare MP-TF activity between non-DIC and DIC groups. Ten clinically healthy beagles and 26 diseased dogs were enrolled. The proportion of dogs with increased MP-TF activity was significantly higher in the DIC group than the non-DIC group (P=0.014). MP-TF activity in the DIC group was significantly higher than the non-DIC group (P=0.021). MP-TF activity positively correlated with plasma D-dimer concentration (r=0.42, P=0.034). Moreover, MP-TF activity was decreased by the time of recovery in some dogs with DIC. Larger prospective studies are warranted to assess its value as a diagnostic and prognostic biomarker in DIC.
Identifiants
pubmed: 31787663
doi: 10.1292/jvms.19-0553
pmc: PMC6983662
doi:
Substances chimiques
Thromboplastin
9035-58-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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