The Consortium for the early identification of Alzheimer's disease-Quebec (CIMA-Q).

Alzheimer's disease Biomarker CIMA-Q Clinical cohort Consortium for the early identification of Alzheimer's disease-Quebec Cryopreserved PBMNC Early diagnosis Mild cognitive impairment Subjective cognitive decline

Journal

Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604

Informations de publication

Date de publication:
Dec 2019
Historique:
entrez: 3 12 2019
pubmed: 4 12 2019
medline: 4 12 2019
Statut: epublish

Résumé

The Consortium for the early identification of Alzheimer's disease-Quebec (CIMA-Q) created a research infrastructure to recruit, characterize, and track disease progression in individuals at risk of dementia. CIMA-Q established standardized clinical, neuropsychological, neuroimaging, blood (plasma, serum, RNA, genomic DNA), cryopreserved peripheral blood mononuclear cells, and cerebrospinal fluid collection protocols. These data and biological materials are available to the research community. In phase 1, 115 persons with subjective cognitive decline, 88 with mild cognitive impairment, 31 with early probable Alzheimer's disease, and 56 older adults with no worries nor impairments received detailed clinical and cognitive evaluations as well as blood and peripheral blood mononuclear cells collections. Among them, 142 underwent magnetic resonance imaging, 29 a CIMA-Q provides procedures and resources to identify early biomarkers and novel therapeutic targets, and holds promise for detecting cognitive decline in Alzheimer's disease.

Identifiants

DOI: 10.1016/j.dadm.2019.07.003 PMID: 31788534 PMC: PMC6880140
pubmed: 31788534
doi: 10.1016/j.dadm.2019.07.003
pii: S2352-8729(19)30054-5
pmc: PMC6880140
doi:

Types de publication

Journal Article

Langues

eng

Pagination

787-796

Investigateurs

Pierre Bellec (P)
Sylvie Belleville (S)
Christian Bocti (C)
Frédéric Calon (F)
Howard Chertkow (H)
Louis Collins (L)
Stephen Cunnane (S)
Simon Duchesne (S)
Pierrette Gaudreau (P)
Serge Gauthier (S)
Sébastien S Hébert (SS)
Carol Hudon Marie-Jeanne-Kergoat (CH)
Andréa C LeBlanc (AC)
Nicole Leclerc (N)
Naguib Mechawar (N)
Natalie Philips (N)
Jean-Paul Soucy (JP)
Thien Thanh Dang Vu (TT)
Louis Verret (L)
Juan Manuel Villalpando (JM)

Informations de copyright

© 2019 The Authors.

Références

Alzheimers Dement. 2018 Nov;14(11):1470-1481
pubmed: 29499171
Lancet. 1993 Sep 18;342(8873):697-9
pubmed: 8103819
J Neurol. 2009 Sep;256(9):1500-9
pubmed: 19434441
Alzheimers Dement. 2011 May;7(3):257-62
pubmed: 21514247
Neuropsychol Rev. 2017 Dec;27(4):328-353
pubmed: 29019061
Arch Neurol. 2004 Aug;61(8):1290-3
pubmed: 15313849
N Engl J Med. 2012 Aug 30;367(9):795-804
pubmed: 22784036
Cochrane Database Syst Rev. 2008 Apr 16;(2):CD005381
pubmed: 18425918
J Intern Med. 2018 Dec;284(6):643-663
pubmed: 30051512
Alzheimers Dement. 2014 Nov;10(6):844-52
pubmed: 24798886
Curr Neurol Neurosci Rep. 2007 Sep;7(5):373-80
pubmed: 17764626
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Biol Psychiatry. 2010 Nov 15;68(10):894-902
pubmed: 20359695
Alzheimers Res Ther. 2018 Aug 7;10(1):76
pubmed: 30081935
Alzheimers Dement. 2011 May;7(3):330-2
pubmed: 21575874
Arch Cardiovasc Dis. 2008 Mar;101(3):181-9
pubmed: 18477946
Eur J Nucl Med Mol Imaging. 2009 May;36(5):811-22
pubmed: 19142633
Alzheimers Dement. 2005 Jul;1(1):55-66
pubmed: 17476317
Arch Gen Psychiatry. 2006 Aug;63(8):916-24
pubmed: 16894068
Can J Neurol Sci. 2019 Sep;46(5):499-511
pubmed: 31309917
Int J Geriatr Psychiatry. 2009 Oct;24(10):1094-100
pubmed: 19280679
Am J Epidemiol. 2006 Mar 1;163(5):433-40
pubmed: 16410348
J Alzheimers Dis. 2019;67(3):893-910
pubmed: 30689579
Alzheimer Dis Assoc Disord. 2004 Oct-Dec;18(4):190-5
pubmed: 15592129
Lancet. 2017 Dec 16;390(10113):2673-2734
pubmed: 28735855
Neurology. 2002 Mar 12;58(5):750-7
pubmed: 11889239
Neurobiol Aging. 2012 Jul;33(7):1203-14
pubmed: 21159408
Open Biol. 2018 Sep;8(9):
pubmed: 30185603
Lancet Neurol. 2003 Feb;2(2):79-88
pubmed: 12849264
Curr Top Med Chem. 2006;6(6):629-47
pubmed: 16712496
Ann Neurol. 2004 Jul;56(1):27-35
pubmed: 15236399
Cochrane Database Syst Rev. 2009 Apr 15;(2):CD003160
pubmed: 19370582
Neurology. 2007 May 8;68(19):1596-602
pubmed: 17485646
Neurology. 2007 May 29;68(22):1902-8
pubmed: 17536046
Alzheimers Dement. 2017 Mar;13(3):296-311
pubmed: 27825022
Ann Nucl Med. 2003 Apr;17(2):79-89
pubmed: 12790355
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Ann Neurol. 2006 Apr;59(4):673-81
pubmed: 16470518
Front Neuroinform. 2012 Jan 20;5:37
pubmed: 22319489
Neurobiol Aging. 2009 Nov;30(11):1724-7
pubmed: 18316138
N Engl J Med. 2000 Aug 17;343(7):450-6
pubmed: 10944562
Alzheimers Dement. 2011 May;7(3):280-92
pubmed: 21514248
Sleep. 2012 Apr 01;35(4):491-9
pubmed: 22467987
J Alzheimers Dis. 2010;20(1):175-83
pubmed: 20164594
J Geriatr Psychiatry Neurol. 2004 Jun;17(2):81-7
pubmed: 15157348
Ann Neurol. 2004 Mar;55(3):306-19
pubmed: 14991808

Auteurs

Sylvie Belleville (S)

Psychology Department, Université de Montréal, Montreal, Canada.
Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, Canada.

Andréa C LeBlanc (AC)

Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Lady Davis Institute, Jewish General Hospital, Montreal, Canada.

Marie-Jeanne Kergoat (MJ)

Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, Canada.
Department of Geriatric, Université de Montréal, Montreal, Canada.

Frédéric Calon (F)

Faculty of Pharmacy, Université Laval, Québec, Canada.
Centre de recherche du CHU de Québec, Université Laval, Québec, Canada.

Pierrette Gaudreau (P)

Department of Medicine, Université de Montréal, Montreal, Canada.
Centre Hospitalier de l'Université de Montréal Research Center, Montreal, Canada.

Sébastien S Hébert (SS)

Centre de recherche du CHU de Québec, Université Laval, Québec, Canada.
Department of Psychiatry and Neurosciences, Université Laval, Québec, Canada.

Carol Hudon (C)

School of Psychology, Université Laval, Québec, Canada.
Centre de recherche CERVO, Institut Universitaire en Santé Mentale de Québec, Quebec, Canada.

Nicole Leclerc (N)

Centre Hospitalier de l'Université de Montréal Research Center, Montreal, Canada.
Department of Neurosciences, Université de Montréal, Montreal, Canada.

Naguib Mechawar (N)

Department of Psychiatry, McGill University, Montreal, Canada.
Douglas Mental Health University Institute, Montreal, Canada.

Simon Duchesne (S)

Centre de recherche CERVO, Institut Universitaire en Santé Mentale de Québec, Quebec, Canada.
Department of Radiology and Nuclear Medicine, Université Laval, Québec, Canada.

Serge Gauthier (S)

Department of Psychiatry, McGill University, Montreal, Canada.
McGill Center for Studies in Aging, Montreal, Canada.

Classifications MeSH