Synthesis, Cytotoxicity and Antimicrobial Evaluation of New Coumarin-Tagged β-Lactam Triazole Hybrid.
Anti-Bacterial Agents
/ chemical synthesis
Antifungal Agents
/ chemical synthesis
Antineoplastic Agents
/ chemical synthesis
Candida albicans
/ drug effects
Cell Proliferation
/ drug effects
Coumarins
/ chemical synthesis
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HEK293 Cells
Humans
MCF-7 Cells
Microbial Sensitivity Tests
Molecular Structure
Pseudomonas aeruginosa
/ drug effects
Structure-Activity Relationship
Triazoles
/ chemistry
beta-Lactams
/ chemistry
1,2,3-triazole
HEK-293
MCF7
MDA-MB-231
biological activity
coumarin
molecular hybridization
synthesis
β-lactam
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
21
08
2019
accepted:
26
11
2019
pubmed:
4
12
2019
medline:
20
2
2020
entrez:
3
12
2019
Statut:
ppublish
Résumé
A series of coumarin-tagged β-lactam triazole hybrids (10a-10o) were synthesized and tested for their cytotoxic activity against MDA-MB-231 (triple negative breast cancer), MCF-7 (estrogen receptor positive breast cancer (ER+)) and A549 (human lung carcinoma) cancer cell lines including one normal cell line, HEK-293 (human embryonic kidney). Two compounds 10b and 10d exhibited substantial cytotoxic effect against MCF-7 cancer cell lines with IC
Identifiants
pubmed: 31788939
doi: 10.1002/cbdv.201900462
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Antineoplastic Agents
0
Coumarins
0
Triazoles
0
beta-Lactams
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900462Subventions
Organisme : Center for High Computing Performance (CHPC) based in Cape Town (South Africa)
Organisme : National Research Foundation (NRF-TWAS)
ID : UID: 99734
Organisme : 'Antimicrobial screening performed by CO-ADD (The Community for Antimicrobial Drug Discovery)
Organisme : Wellcome Trust (UK)
Organisme : The University of Queensland (Australia)'
Organisme : NRF
ID : 109163
Informations de copyright
© 2019 Wiley-VHCA AG, Zurich, Switzerland.
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