Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data.
DNA methylation
EWAS
HM450 assay
alcohol consumption
cross-sectional data
epigenome-wide association study
longitudinal data
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
25
10
2018
revised:
29
09
2019
accepted:
04
11
2019
pubmed:
4
12
2019
medline:
10
9
2021
entrez:
3
12
2019
Statut:
ppublish
Résumé
DNA methylation may be one of the mechanisms by which alcohol consumption is associated with the risk of disease. We conducted a large-scale, cross-sectional, genome-wide DNA methylation association study of alcohol consumption and a longitudinal analysis of repeated measurements taken several years apart. Using the Illumina HumanMethylation450 BeadChip, DNA methylation was measured in blood samples from 5606 Melbourne Collaborative Cohort Study (MCCS) participants. For 1088 of them, these measures were repeated using blood samples collected a median of 11 years later. Associations between alcohol intake and blood DNA methylation were assessed using linear mixed-effects regression models. Independent data from the London Life Sciences Prospective Population (LOLIPOP) (N = 4042) and Cooperative Health Research in the Augsburg Region (KORA) (N = 1662) cohorts were used to replicate associations discovered in the MCCS. Cross-sectional analyses identified 1414 CpGs associated with alcohol intake at P < 10
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12855Subventions
Organisme : British Heart Foundation
ID : SP/04/002
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098381
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 090532
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 084723/Z/08/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0700931
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0601966
Pays : United Kingdom
Informations de copyright
© 2019 Society for the Study of Addiction.
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