The right VLPFC and downregulation of social pain: A TMS study.
emotion regulation
event-related potential
physical pain
social pain
transcranial magnetic stimulation
ventrolateral prefrontal cortex
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
27
09
2019
revised:
04
11
2019
accepted:
19
11
2019
pubmed:
4
12
2019
medline:
18
9
2021
entrez:
3
12
2019
Statut:
ppublish
Résumé
Previous studies have demonstrated that the right ventrolateral prefrontal cortex (RVLPFC) is crucially involved in downregulating physical and social pain. However, it remains unclear whether the RVLPFC is more specific to either physical or social pain. The present study compares the role of RVLPFC in emotion regulation in physical- and social-pain conditions using repetitive transcranial magnetic stimulation (rTMS). A total of 60 healthy participants underwent active (n = 30) or sham (n = 30) rTMS over the RVLPFC. Following each TMS session, participants performed a non-reappraisal and then a reappraisal task to downregulate imagined physical or social pain evoked by pictures. Self-reported negative emotional ratings and electroencephalogram data were recorded during the emotion regulation task. Participants were then required to rate the valence and arousal of those pictures 30 min after the task. It is found that rTMS-activated RVLPFC led to reductions in subjective negative feelings and amplitudes of the late positive potential during reappraisal; however, these effects were found exclusively in the social-pain condition. Participants also reported higher positive valence for socially, compared to physically, painful pictures after 30 min of the task. Behavioral and electrophysiological evidence both supported the functional specificity of RVLPFC in regulation of social pain. The prominent delayed effect of rTMS makes it possible to consider the potential application of rTMS-VLPFC in clinical practice for social pain relief.
Identifiants
pubmed: 31789480
doi: 10.1002/hbm.24881
pmc: PMC7267938
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1362-1371Informations de copyright
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
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