Sources of variability in expiratory flow profiles during sleep in healthy young children.
Airway obstruction
Flow-volume curves
Impedance pneumography
Sleep stages
Tidal breathing
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
17
09
2019
revised:
21
10
2019
accepted:
18
11
2019
pubmed:
4
12
2019
medline:
13
4
2021
entrez:
3
12
2019
Statut:
ppublish
Résumé
Standard lung function tests are not feasible in young children, but recent studies show that the variability of expiratory tidal breathing flow-volume (TBFV) curves during sleep is a potential indirect marker of lower airway obstruction. However, the neurophysiological sources of the TBFV variability in normal subjects has not been established. We investigated sleep stages and body position changes as potential sources for the TBFV curve variability. Simultaneous impedance pneumography (IP), polysomnography (PSG) and video recordings were done in 20 children aged 1.4-6.9 years without significant respiratory disorders during sleep. The early part of expiratory TBFV curves are less variable between cycles of REM than NREM sleep. However, within individual sleep cycles, TBFV curves during N3 are the least variable. The differences in TBFV curve shapes between sleep stages are the main source of overnight variability in TBFV curves and the changes in body position have a lesser impact.
Identifiants
pubmed: 31790764
pii: S1569-9048(19)30334-9
doi: 10.1016/j.resp.2019.103352
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103352Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.