Transcription through the nucleosome.
Journal
Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
12
08
2019
revised:
17
10
2019
accepted:
22
10
2019
pubmed:
4
12
2019
medline:
8
6
2021
entrez:
3
12
2019
Statut:
ppublish
Résumé
Eukaryotic genomic DNA is wrapped around the histone octamer and forms the nucleosome, which is the basic unit of chromatin. Nevertheless, eukaryotic RNA polymerases transcribe the DNA that is tightly bound to the histone core in the nucleosome. For transcription to proceed on the nucleosome, the RNA polymerases must overcome the tight contacts between histones and DNA during transcription elongation. Here, we review the structural and biochemical studies of the transcription mechanism on the nucleosome, and focus on recent information to understand how RNA polymerases transcribe the genomic DNA in chromatin.
Identifiants
pubmed: 31790919
pii: S0959-440X(19)30117-4
doi: 10.1016/j.sbi.2019.10.007
pii:
doi:
Substances chimiques
Chromatin
0
DNA-Binding Proteins
0
Histones
0
Nucleosomes
0
RNA Polymerase II
EC 2.7.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-49Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.