MIF -173G/C polymorphism is associated with NMO disease severity.
Autoimmune
Biomarker
Expanded disability status score
Macrophage migration inhibitory factor
Neuromyelitis optica
Single nucleotide polymorphism
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 02 2020
15 02 2020
Historique:
received:
25
09
2019
revised:
15
11
2019
accepted:
25
11
2019
pubmed:
4
12
2019
medline:
10
7
2020
entrez:
3
12
2019
Statut:
ppublish
Résumé
Our knowledge about genetic factors that drive the worsening of neuromyelitis optica (NMO) is limited. Herein, we analyzed the macrophage migration inhibitory factor (MIF) -173G/C functional polymorphism in NMO patients and controls. Our data reveal that the frequency of the high-expression MIF genotypes (CC/GC) did not differ between the two groups. However, frequency of this genotypes was elevated in patients diagnosed with both optic neuritis and myelitis compared with patients that were diagnosed with only one symptom. Furthermore, patients carrying the CC/CG genotypes had significantly higher disability score. We conclude that MIF is associated with NMO severity rather than susceptibility.
Identifiants
pubmed: 31790982
pii: S0165-5728(19)30503-X
doi: 10.1016/j.jneuroim.2019.577120
pii:
doi:
Substances chimiques
Macrophage Migration-Inhibitory Factors
0
Intramolecular Oxidoreductases
EC 5.3.-
MIF protein, human
EC 5.3.2.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577120Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.