Relationship between diffusion capacity and small airway abnormality in COPDGene.
Aged
Airway Obstruction
/ diagnostic imaging
Airway Remodeling
/ physiology
Bronchioles
/ abnormalities
Carbon Monoxide
/ metabolism
Cohort Studies
Female
Humans
Male
Middle Aged
Multivariate Analysis
Pulmonary Diffusing Capacity
Pulmonary Disease, Chronic Obstructive
/ diagnostic imaging
Pulmonary Emphysema
/ diagnostic imaging
Regression Analysis
Respiratory Function Tests
Retrospective Studies
Severity of Illness Index
Tomography, X-Ray Computed
/ methods
Chronic obstructive pulmonary disease (COPD)
Diffusing capacity of the lung (DLCO)
Parametric response mapping (PRM)
Small airways disease (SAD)
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
02 Dec 2019
02 Dec 2019
Historique:
received:
21
09
2019
accepted:
08
11
2019
entrez:
4
12
2019
pubmed:
4
12
2019
medline:
6
5
2020
Statut:
epublish
Résumé
Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. TRIAL REGISTRATION: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.
Identifiants
pubmed: 31791337
doi: 10.1186/s12931-019-1237-1
pii: 10.1186/s12931-019-1237-1
pmc: PMC6889734
doi:
Substances chimiques
Carbon Monoxide
7U1EE4V452
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
269Subventions
Organisme : Novartis
ID : None
Organisme : NHLBI NIH HHS
ID : U01 HL089897
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139690
Pays : United States
Organisme : Sunovion
ID : None
Organisme : CSRD VA
ID : I01 CX000911
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL138188
Pays : United States
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