Brain functional connectivity data enhance prediction of clinical outcome in youth at risk for psychosis.
Clinical high risk
Connectome
Cross-validation
Prediction
Resting-state functional connectivity
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
06
2019
revised:
18
11
2019
accepted:
19
11
2019
pubmed:
4
12
2019
medline:
17
2
2021
entrez:
4
12
2019
Statut:
ppublish
Résumé
The first episode of psychosis is typically preceded by a prodromal phase with subthreshold symptoms and functional decline. Improved outcome prediction in this stage is needed to allow targeted early intervention. This study assesses a combined clinical and resting-state fMRI prediction model in 137 adolescents and young adults at Clinical High Risk (CHR) for psychosis from the Shanghai At Risk for Psychosis (SHARP) program. Based on outcome at one-year follow-up, participants were separated into three outcome categories including good outcome (symptom remission, N = 71), intermediate outcome (ongoing CHR symptoms, N = 30), and poor outcome (conversion to psychosis or treatment-refractory, N = 36). Validated clinical predictors from the psychosis-risk calculator were combined with measures of resting-state functional connectivity. Using multinomial logistic regression analysis and leave-one-out cross-validation, a clinical-only prediction model did not achieve a significant level of outcome prediction (F
Identifiants
pubmed: 31791912
pii: S2213-1582(19)30455-3
doi: 10.1016/j.nicl.2019.102108
pmc: PMC7229353
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
102108Subventions
Organisme : NIMH NIH HHS
ID : R01 MH111448
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH093294
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH064023
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101052
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108574
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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