Individual prediction of psychotherapy outcome in posttraumatic stress disorder using neuroimaging data.
Adult
Cognitive Behavioral Therapy
/ methods
Connectome
/ standards
Feasibility Studies
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Outcome Assessment, Health Care
/ standards
Proof of Concept Study
Psychological Trauma
/ complications
Sensitivity and Specificity
Stress Disorders, Post-Traumatic
/ diagnostic imaging
Veterans
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
02 12 2019
02 12 2019
Historique:
received:
12
09
2019
accepted:
01
11
2019
revised:
30
09
2019
entrez:
4
12
2019
pubmed:
4
12
2019
medline:
22
9
2020
Statut:
epublish
Résumé
Trauma-focused psychotherapy is the first-line treatment for posttraumatic stress disorder (PTSD) but 30-50% of patients do not benefit sufficiently. We investigated whether structural and resting-state functional magnetic resonance imaging (MRI/rs-fMRI) data could distinguish between treatment responders and non-responders on the group and individual level. Forty-four male veterans with PTSD underwent baseline scanning followed by trauma-focused psychotherapy. Voxel-wise gray matter volumes were extracted from the structural MRI data and resting-state networks (RSNs) were calculated from rs-fMRI data using independent component analysis. Data were used to detect differences between responders and non-responders on the group level using permutation testing, and the single-subject level using Gaussian process classification with cross-validation. A RSN centered on the bilateral superior frontal gyrus differed between responders and non-responder groups (P
Identifiants
pubmed: 31792202
doi: 10.1038/s41398-019-0663-7
pii: 10.1038/s41398-019-0663-7
pmc: PMC6889413
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
326Références
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