Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 12 2019
02 12 2019
Historique:
received:
03
05
2019
accepted:
11
11
2019
entrez:
4
12
2019
pubmed:
4
12
2019
medline:
5
3
2020
Statut:
epublish
Résumé
Interactions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that account for their age-specific properties, including proliferation rates, engraftability and function. Further analyses identify Myc as a regulator of fetal thymus development to support the rapid increase of thymus size during fetal life. Enforced Myc expression in TEC induces the prolonged maintenance of a fetal-specific transcriptional program, which in turn extends the growth phase of the thymus and enhances thymic output; meanwhile, inducible expression of Myc in adult TEC similarly promotes thymic growth. Mechanistically, this Myc function is associated with enhanced ribosomal biogenesis in TEC. Our study thus identifies age-specific transcriptional programs in TEC, and establishes that Myc controls thymus size.
Identifiants
pubmed: 31792212
doi: 10.1038/s41467-019-13465-y
pii: 10.1038/s41467-019-13465-y
pmc: PMC6889275
doi:
Substances chimiques
Oncogene Protein p55(v-myc)
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5498Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 1 ZIA BC011633
Pays : International
Références
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Nature. 2018 Mar 22;555(7697):457-462
pubmed: 29513653
Genome Biol. 2003;4(10):R69
pubmed: 14519204
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9885-90
pubmed: 23720310
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11822-7
pubmed: 9751749
Nature. 2011 Oct 09;479(7372):189-93
pubmed: 21983963
Nat Cell Biol. 2019 Jun;21(6):700-709
pubmed: 31061465
Cell. 2004 Apr 2;117(1):107-16
pubmed: 15066286
Cell. 2012 Sep 28;151(1):68-79
pubmed: 23021216
Cell Rep. 2016 Mar 29;14(12):2819-32
pubmed: 26997270
Nature. 1999 Aug 12;400(6745):682-7
pubmed: 10458165
Blood. 2006 Dec 1;108(12):3777-85
pubmed: 16896157
Nat Rev Cancer. 2010 Apr;10(4):301-9
pubmed: 20332779
Nat Rev Cancer. 2008 Dec;8(12):976-90
pubmed: 19029958
Biol Cell. 2004 Sep;96(7):479-98
pubmed: 15380615
Blood. 2009 May 21;113(21):5186-91
pubmed: 19289856
Nat Immunol. 2002 Jul;3(7):635-42
pubmed: 12068292
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20572-7
pubmed: 23188800
J Exp Med. 2013 Jun 3;210(6):1087-97
pubmed: 23669396
J Immunol. 1986 Oct 1;137(7):2115-21
pubmed: 3093565
Nature. 2018 Jul;559(7715):622-626
pubmed: 30022162
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
Nat Immunol. 2014 Jun;15(6):554-61
pubmed: 24728352
Immunity. 2018 Jun 19;48(6):1258-1270.e6
pubmed: 29884461
J Immunol. 2000 Feb 15;164(4):1881-8
pubmed: 10657637
Nucleic Acids Res. 2013 May 1;41(10):e108
pubmed: 23558742
Cell Cycle. 2006 Aug;5(15):1621-8
pubmed: 16921263
Nat Immunol. 2012 Nov;13(11):1092-100
pubmed: 23001146
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7634-8
pubmed: 8755527
J Immunol. 2015 May 15;194(10):4784-95
pubmed: 25870244
Nat Rev Immunol. 2017 May;17(5):295-305
pubmed: 28317923
Nature. 2001 Dec 13;414(6865):768-73
pubmed: 11742404
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Genome Res. 2015 Dec;25(12):1860-72
pubmed: 26430063
Methods Mol Biol. 2016;1323:203-9
pubmed: 26294410
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Mol Cell Biol. 1999 Jan;19(1):1-11
pubmed: 9858526
Biochim Biophys Acta. 2015 May;1849(5):544-53
pubmed: 24727092
Cancer Res. 2007 Oct 15;67(20):9762-70
pubmed: 17942906
BMC Bioinformatics. 2013 Jan 16;14:7
pubmed: 23323831
J Immunol. 2009 Mar 1;182(5):2997-3007
pubmed: 19234195
Nat Immunol. 2004 Apr;5(4):418-25
pubmed: 14991052
Nat Genet. 2008 May;40(5):499-507
pubmed: 18443585
Genes Dev. 2019 Aug 1;33(15-16):1048-1068
pubmed: 31221665
Cell Mol Life Sci. 2007 Jan;64(1):29-49
pubmed: 17171232
Nat Cell Biol. 2018 Mar;20(3):285-295
pubmed: 29476152
Blood. 2014 Jun 19;123(25):3909-13
pubmed: 24795346
Eur J Immunol. 2008 Feb;38(2):342-9
pubmed: 18196519
Semin Cancer Biol. 2006 Aug;16(4):288-302
pubmed: 16938463
Genome Biol. 2015 Dec 10;16:278
pubmed: 26653891
Science. 2010 Nov 19;330(6007):1099-102
pubmed: 21097934
RNA. 2009 Jan;15(1):104-15
pubmed: 19029303
J Immunol. 2016 Aug 15;197(4):1498-506
pubmed: 27385780
Cell Rep. 2019 Nov 26;29(9):2901-2916.e6
pubmed: 31775054